The Companion Dog as a Model for the Longevity Dividend
The Companion Dog as a Model for the Longevity Dividend
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DOI：
10.1101/cshperspect.a026633
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发表时间：
2016-01-01
影响因子：
5.4
通讯作者：
Promislow, Daniel E. L.
中科院分区：
文献类型：
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作者：
Creevy, Kate E.;Austad, Steven N.;Promislow, Daniel E. L.
伴侣犬是地球上最具表型多样性的物种。品种之间的巨大差异不仅延伸到形态和行为，而且还延伸到影响狗的寿命和疾病。人类和犬类之间有着显著的重叠和相似之处。狗与我们的人类环境密切相关，包括许多风险因素，管理狗健康的兽医基础设施仅次于人类的医疗基础设施。独特的品种为基础的健康档案，沿着其发达的健康记录系统和高度重叠的人类环境，使伴侣犬一个特殊的模式，以提高对生理，社会和经济影响的长寿红利（LD）的理解。在这篇综述中，我们描述了什么是已经知道的特定年龄的发病率和死亡率的模式，在伴侣犬，然后探讨现有的证据是否支持LD。我们还讨论了使用狗作为衰老模型的一些潜在限制，包括许多狗在度过自然寿命之前就被安乐死的事实。总体而言，我们的结论是，伴侣狗提供了高潜力的模型系统，将使更深入的研究LD比其他可能的。
The companion dog is the most phenotypically diverse species on the planet. This enormous variability between breeds extends not only to morphology and behavior but also to longevity and the disorders that affect dogs. There are remarkable overlaps and similarities between the human and canine species. Dogs closely share our human environment, including its many risk factors, and the veterinary infrastructure to manage health in dogs is second only to the medical infrastructure for humans. Distinct breed-based health profiles, along with their well-developed health record system and high overlap with the human environment, make the companion dog an exceptional model to improve understanding of the physiological, social, and economic impacts of the longevity dividend (LD). In this review, we describe what is already known about age-specific patterns of morbidity and mortality in companion dogs, and then explore whether this existing evidence supports the LD. We also discuss some potential limitations to using dogs as models of aging, including the fact that many dogs are euthanized before they have lived out their natural life span. Overall, we conclude that the companion dog offers high potential as a model system that will enable deeper research into the LD than is otherwise possible.