Association of adiponectin and resistin with cardiovascular events in Korean patients with type 2 diabetes: The Korean atherosclerosis study (KAS) A 42-month prospective study
Association of adiponectin and resistin with cardiovascular events in Korean patients with type 2 diabetes: The Korean atherosclerosis study (KAS) A 42-month prospective study
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DOI：
10.1016/j.atherosclerosis.2006.11.017
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发表时间：
2008-01-01
期刊：
影响因子：
5.3
通讯作者：
Park, Kyong Soo
中科院分区：
文献类型：
--
作者：
Lim, Soo;Koo, Bo Kyeong;Park, Kyong Soo
脂联素和脂联素是影响胰岛素抵抗和动脉粥样硬化的重要蛋白质。我们研究了脂联素和脂联素浓度作为韩国2型糖尿病患者心血管事件的预测因子。2001年的研究包括343名无关的2型糖尿病患者（65 +/-9.2岁）。随访42个月。记录基线糖尿病病程、吸烟情况和心血管疾病史。测量BMI、血压、HbA1c、血脂、ECG、肌酐和尿微量白蛋白。采用酶联免疫吸附试验测定脂联素和β-淀粉样蛋白。主要终点定义为心血管死亡、心肌梗死、CABG、卒中、不稳定型心绞痛或明显肾病。38例患者（11。1%）在随访期间经历了主要终点。调整年龄、性别、BMI、血压和血脂状态后，脂联素水平最低四分位数的参与者与最高四分位数的参与者相比，主要终点的风险显著增加（相对风险= 3.03; 95%CI 1.09 - 8.41; p = 0.034）。相比之下，肌酐水平对主要终点的风险没有影响。在这些韩国2型糖尿病患者中，低水平的脂联素（而非脂联素）是发生心血管事件的重要危险因素。(c)2006爱思唯尔爱尔兰有限公司保留所有权利。
Adiponectin and resistin are proteins that affect insulin resistance and atherosclerosis significantly. We investigated adiponectin and resistin concentrations as predictors of cardiovascular events in Korean patients with type 2 diabetes. The study in 2001 comprised 343 unrelated patients with type 2 diabetes (65 +/- 9.2 years old). They were followed up for 42 months. The baseline duration of diabetes, smoking status and history of cardiovascular diseases (CVD) were recorded. BMI, blood pressures, HbA1c, lipid profiles, ECG, creatinine and urine microalbumin were measured. Adiponectin and resistin were measured using enzyme-linked immunosorbent assays. The primary endpoint was defined as one of cardiovascular death, myocardial infarct, CABG, stroke, unstable angina or overt nephropathy. Thirty-eight patients (11. 1 %) experienced primary endpoint during the follow-up. After adjustment for age, sex, BMI, blood pressure and lipid status, participants in the lowest quartile of adiponectin levels compared with the highest had significantly increased risk of primary endpoint (relative risk = 3.03; 95% CI 1.09-8.41; p = 0.034). In contrast, resistin level had no influence on the risk of primary endpoint. A low level of adiponectin, not resistin, was a significant risk factor for the development of cardiovascular events in these Korean patients with type 2 diabetes. (c) 2006 Elsevier Ireland Ltd. All rights reserved.