Nosocomial person-to-person transmission of severe fever with thrombocytopenia syndrome
Nosocomial person-to-person transmission of severe fever with thrombocytopenia syndrome
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DOI：
10.1016/j.cmi.2019.01.006
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发表时间：
2019-05-01
影响因子：
14.2
通讯作者：
Kim, Y. K.
中科院分区：
文献类型：
--
作者：
Jung, I. Y.;Choi, W.;Kim, Y. K.
目的：对卫生保健工作者（HCWs）接触首例患者后院内发热伴血小板减少综合征病毒（SFTSV）传播情况进行流行病学调查。本研究的目的是确定接触血液或血性呼吸道分泌物是否与SFTSV的人际传播有关。方法：患者死亡11天后，与患者密切接触的2名医护人员出现典型的SFTS症状。卫生署对所有曾与该病人密切接触的25名医护人员进行流行病学调查。收集临床和实验室资料，分析指标患者出现出血症状前后的传播率。结果：25名直接接触患者的医护人员中，有5名确诊为SFTS。所有5名卫生保健员均在未充分使用个人防护装备的情况下接触了该患者的血液或带血的呼吸道分泌物。该指数患者在出现出血热症状前未与人接触。总体而言，在指标患者出现出血症状后接触的医护人员的传播率更高（33.3%，15名医护人员中有5名；0%，10名医护人员中有0名，p 0.041）。结论：在防护不充分的卫生工作者中，SFTSV的人际传播可能与接触血液或带血的呼吸道分泌物有关。因此，当有出血迹象时，强烈建议采取普遍的预防措施和全套个人防护装备来预防SFTSV。(C) 2019年欧洲临床微生物学和传染病学会。Elsevier Ltd.出版。版权所有。
Objectives: This study is an epidemiologic investigation of nosocomial severe fever with thrombocytopenia syndrome virus (SFTSV) transmission among healthcare workers (HCWs) after contact with an index patient. The aim of this study was to determine whether exposure to blood or bloody respiratory secretion is associated with human-to-human transmission of SFTSV.Methods: Eleven days after the index patient died, two HCWs who had close exposure to the patient presented with typical symptoms of SFTS. An epidemiological investigation was conducted on all 25 HCWs who had been in close contact with the index patient. Clinical and laboratory data were collected, and transmission rate before and after the index patient had haemorrhagic manifestations was analysed.Results: Among 25 HCWs who had direct contact with the index patient, five HCWs were confirmed to have SFTS. All five HCWs had contact to blood or bloody respiratory secretions of the index patient without adequate use of personal protective equipment (PPE). No HCW with contact before haemorrhagic manifestations of the index patient contracted SFTS. Overall, the transmission rate was higher for HCWs who had contact after the index patient had haemorrhagic manifestations (33.3%, five of 15 HCWs, vs. 0%, zero of ten HCWs, p 0.041).Conclusions: In HCWs who are inadequately protected, person-to-person transmission of SFTSV may be associated with contact with blood or bloody respiratory secretions. Therefore, universal precaution and full PPE is highly recommended for protection against SFTSV when there are signs of bleeding. (C) 2019 European Society of Clinical Microbiology and Infectious Diseases. Published by Elsevier Ltd. All rights reserved.