An overview of the cannabinoid type 2 receptor system and its therapeutic potential.
An overview of the cannabinoid type 2 receptor system and its therapeutic potential.
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DOI：
10.1097/aco.0000000000000616
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发表时间：
2018-08
期刊：
影响因子：
--
通讯作者：
Naguib M
中科院分区：
文献类型：
--
作者：
Bie B;Wu J;Foss JF;Naguib M
本文综述了近年来CB2受体在神经病理性疼痛和神经退行性疾病中作为潜在治疗靶点的作用。大麻素系统作为治疗靶点继续受到关注。大麻素2型（CB2）受体主要仅在存在活动性炎症时表达，并且似乎没有不希望的精神作用或成瘾倾向。CB2受体已被证明在具有有限或没有目前批准的疗法的疾病模型中具有作为治疗靶标的潜力，所述疾病例如神经性疼痛和神经变性病症例如阿尔茨海默病。CB2受体在神经病理性疼痛和其他神经炎性疾病中的功能参与突出了作用于CB2受体的药物的潜在治疗作用。
This narrative review summarizes recent insights into the role of the CB2 receptor as potential therapeutic target in neuropathic pain and neurodegenerative conditions. The cannabinoid system continues to receive attention as a therapeutic target. The cannabinoid type 2 (CB2) receptor is primarily expressed only when there is active inflammation and appears to be devoid of undesired psychotropic effects or addiction liability. The CB2 receptor has been shown to have potential as a therapeutic target in models of diseases with limited or no currently approved therapies, such as neuropathic pain and neurodegenerative conditions such as Alzheimer’s disease. The functional involvement of CB2 receptor in neuropathic pain and other neuroinflammatory diseases highlights the potential therapeutic role of drugs acting at the CB2 receptor.