RELATIONSHIP BETWEEN LABORATORY MICE AND THE SUBSPECIES MUS MUSCULUS DOMESTICUS BASED ON RESTRICTION ENDONUCLEASE CLEAVAGE PATTERNS OF MITOCHONDRIAL DNA
RELATIONSHIP BETWEEN LABORATORY MICE AND THE SUBSPECIES MUS MUSCULUS DOMESTICUS BASED ON RESTRICTION ENDONUCLEASE CLEAVAGE PATTERNS OF MITOCHONDRIAL DNA
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基于线粒体DNA限制性内切酶切割模式的实验小鼠与家鼠亚种的关系
DOI：
10.1266/jjg.55.289
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发表时间：
1980
期刊：
影响因子：
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通讯作者：
Y. Tagashira
中科院分区：
文献类型：
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作者：
H. Yonekawa;K. Moriwaki;O. Gotoh;J. Watanabe;J. Hayashi;N. Miyashita;M. Petras;Y. Tagashira
用9种不同的限制性内切酶对25种不同实验室品系的家鼠线粒体DNA进行酶切，结果表明，它们的酶切模式完全相同。卵裂模式与加拿大野生小鼠M. M.但明显不同于三个亚洲亚种，M。M. bactrianus，M. M. castaneus和M. M. Molossinus。通过对4个亚种的卵裂图比较，确定了M. M.估计该物种的年龄为1-2.5×106年。这些结果表明，实验小鼠的遗传背景主要来源于M。M.阿提库斯
The mitochondrial DNAs of house mouse, Mus musculus in twenty-five different laboratory strains showed identical cleavage patterns on digestion with nine different restriction endonucleases. The cleavage patterns were identical to those of Canadian wild mice, M. m. domesticus but clearly different from the patterns of three Asian subspecies, M. m. bactrianus, M. m. castaneus and M. m. molossinus. Based on comparison of the cleavage maps of the four subspecies, the time of divergence between M. m. domesticus and three Asian subspecies was estimated to be 1-2.5×106 years. These results suggest that the genetic background of laboratory mice is mainly derived from M. m. domesticus.