Water and metabolite transverse T2 relaxation time abnormalities in the white matter in schizophrenia
Water and metabolite transverse T2 relaxation time abnormalities in the white matter in schizophrenia
复制标题
DOI：
10.1016/j.schres.2012.01.026
复制
发表时间：
2012-05-01
影响因子：
4.5
通讯作者：
Oenguer, Dost
中科院分区：
文献类型：
--
作者：
Du, Fei;Cooper, Alissa;Oenguer, Dost
多种证据表明白质的微观结构异常在精神分裂症的病理生理学中很重要。可以提供组织结构证据的扩散 MRI 方法已被广泛用于探测体内的这些异常，但横向弛豫时间 (T2) 可能提供额外的见解，因为它们是由扩散 MRI 未揭示的分子-微环境相互作用决定的。水的 T2（位于细胞内和细胞外）和 N-乙酰天冬氨酸（NAA - 位于细胞内）反映了相关但不同的过程，因为它们的定位不同以及与其他分子的相互作用。在这项研究中，我们收集了 16 名健康受试者 (HC) 和 16 名精神分裂症患者 (SZ) 右侧前额叶白质 9 cm(3) 体素 4 T 下的水和 NAA T2 数据。与 HC 组相比，SZ 组的水较长，但 NAA T2 弛豫时间较短。这种模式导致了具有统计显着性的代谢组相互作用（F(18,1):4.980，p=0.039）。水 T2 的延长和 NAA T2 的缩短与 SZ 中白质大分子结构（包括髓磷脂）的贫化以及异常的轴突内环境和体积一致。 (C) 2012 Elsevier B.V. 保留所有权利。
Multiple lines of evidence suggest that microstructural abnormalities in the white matter are important in the pathophysiology of schizophrenia. Diffusion MRI approaches which can provide evidence on tissue structure have been widely used to probe these abnormalities in vivo, but transverse relaxation times (T2) may provide additional insights since they are determined by molecule-microenvironment interactions not revealed by diffusion MRI. T2 of water - located both intra and extracellularly - and N-acetylaspartate (NAA - located intracellularly) reflect related but distinct processes due to their differential localization and interactions with other molecules. In this study, we collected water and NAA T2 data from 16 healthy subjects (HC), and 16 patients with schizophrenia (SZ) at 4 T in a 9 cm(3) voxel in the right prefrontal white matter. The SZ group had longer water but shorter NAA T2 relaxation times when compared with the HC group. This pattern resulted in a statistically significant metabolitexgroup interaction (F(18,1):4.980, p=0.039). Prolongation of water T2 and shortening of NAA T2 is consistent with an impoverishment of white matter macromolecule structures (including myelin) and abnormal intra-axonal milieu and volume in SZ. (C) 2012 Elsevier B.V. All rights reserved.