The prognostic value of cyclin D1 in renal cell carcinoma
The prognostic value of cyclin D1 in renal cell carcinoma
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DOI：
10.1007/s11255-013-0602-0
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发表时间：
2014-05-01
影响因子：
2
通讯作者：
Barros-Silva, G. E.
中科院分区：
文献类型：
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作者：
Lima, M. S.;Pereira, R. A.;Barros-Silva, G. E.
肾细胞癌（RCC）是一个独特的肿瘤家族，各种分子已被评估为RCC的预后标志物。细胞周期蛋白D1是一种细胞周期调节因子，在几种原发性肿瘤中过表达。为了评估细胞周期蛋白D1表达作为RCC预后标志物的价值，从2005年到2010年，在巴西USP的Hospital das Clinicas-Ribeiro Preto School of Medicine-USP，共获得了109例RCC患者的肿瘤标本，沿着7例正常肾组织标本进行免疫组化分析，所有正常肾组织标本均无cyclin D1免疫组化染色。此外，在乳头状和嫌色细胞RCC样品中有较低的蛋白表达。细胞周期蛋白D1（低）肿瘤患者（千分之一货币符号30%阳性细胞）显示更差的临床结果（p = 0.03），RCC患者无转移和/或死亡的生存率较低（p = 0.03），高细胞核级别（p = 0.001）、较大的肿瘤尺寸（p = 0.01）、诊断时存在症状（p = 0.04）、坏死（p = 0.004）和肉瘤样形态（p = 0.04）。多因素分析后，细胞周期蛋白D1不是一个独立的显着因素，更糟糕的结果，但它提高了所采用的预后系统的准确性。单独透明细胞肾细胞癌的分析显示与总病例相似的统计学意义，Cyclin D1蛋白在肾细胞癌中过表达。肾细胞癌的类型似乎表现出不同的免疫组化染色模式的细胞周期蛋白D1，高蛋白表达与良好的临床结果和最已知的有利预后因素。进一步的研究是必要的，以揭示哪些机制导致细胞周期蛋白D1在肿瘤细胞中的积累。
Renal cell carcinoma (RCC) is a family of distinct tumors, and a variety of molecules have been evaluated as prognostic markers for RCC. Cyclin D1, a cell cycle regulator, is overexpressed in several primary tumors.To evaluate cyclin D1 expression as a prognostic marker in RCC.In total, 109 tumor specimens from patients with RCC were obtained from 2005 to 2010 at Hospital das Clinicas-Ribeiro Preto School of Medicine-USP, Brazil, and submitted to immunohistochemical analysis along with seven normal kidney tissue samples.All of the normal kidney samples lacked cyclin D1 immunohistochemical staining. In addition, there was lower protein expression in the papillary and chromophobe RCC samples. Patients with cyclin D1(low) tumors (a parts per thousand currency sign30 % positive cells) showed worse clinical outcome (p = 0.03), lower survival without metastasis and/or death by RCC (p = 0.03), high nuclear grade (p = 0.001), larger tumor size (p = 0.01), presence of symptoms at diagnosis (p = 0.04), necrosis (p = 0.004) and sarcomatoid morphology (p = 0.04). After multivariate analysis, cyclin D1 was not an independent significant factor for worse outcome; however, it improved the accuracy of the adopted prognostic system. The analysis performed for clear cell RCC alone showed similar statistical significance to that of the total cases.Cyclin D1 protein was overexpressed in RCC. The types of RCC appear to exhibit different immunohistochemical staining patterns for cyclin D1; high protein expression was related to good clinical outcome and to most known favorable prognostic factors. Further investigations are necessary to reveal which mechanisms lead to cyclin D1 accumulation in neoplastic cells.