A thermosensitive hydrogel based on biodegradable amphiphilic poly(ethylene glycol)-polycaprolactone-poly(ethylene glycol) block copolymers
A thermosensitive hydrogel based on biodegradable amphiphilic poly(ethylene glycol)-polycaprolactone-poly(ethylene glycol) block copolymers
复制标题
DOI：
10.1088/0964-1726/16/3/043
复制
发表时间：
2007-06-01
影响因子：
4.1
通讯作者：
Wei, YuQuan
中科院分区：
文献类型：
--
作者：
Gong, ChangYang;Qian, ZhiYong;Wei, YuQuan
以异佛尔酮二异氰酸酯(IPDI)为偶联剂，合成了一系列可生物降解的低相对分子质量聚乙二醇聚己内酯聚乙二醇聚己内酯聚乙二醇嵌段共聚物，并用核磁共振氢谱和傅里叶变换红外光谱对其进行了表征。当浓度高于相应的临界凝胶浓度时，共聚物的水溶液表现出特殊的热敏凝胶-溶胶转变。用试管倒置法记录了凝胶-溶胶相图，它们取决于大分子结构中的亲水/疏水平衡，以及其他一些因素，包括共聚物水溶液的加热历史、体积、老化时间和共聚物的溶解温度。因此，凝胶-溶胶的转变温度范围可以改变，这可能是非常有用的注射给药系统的应用。
A series of low molecular weight poly(ethylene glycol)-polycaprolactone-poly(ethylene glycol) (PEG-PCL-PEG) biodegradable block copolymers were successfully synthesized using isophorone diisocyanate (IPDI) as the coupling agent, and were characterized using H-1 NMR and Fourier transform infrared spectroscopy. The aqueous solutions of the PEG-PCL-PEG copolymers displayed a special thermosensitive gel-sol transition when the concentration was above the corresponding critical gel concentration. Gel-sol phase diagrams were recorded using the test-tube-inversion method; they depended on the hydrophilic/hydrophobic balance in the macromolecular structure, as well as some other factors, including the heating history, volume, and the ageing time of the copolymer aqueous solutions and dissolution temperature of the copolymers. As a result, the gel-sol transition temperature range could be altered, which might be very useful for application in injectable drug delivery systems.