Insulin-like growth factors and bone mineral density in African American and White girls.
Insulin-like growth factors and bone mineral density in African American and White girls.
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DOI：
10.1067/mpd.2000.109151
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发表时间：
2000-12
期刊：
影响因子：
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通讯作者：
J. Yanovski;K. Sovik;T. T. Nguyen-T.;N. Sebring
中科院分区：
文献类型：
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作者：
J. Yanovski;K. Sovik;T. T. Nguyen-T.;N. Sebring
非裔美国儿童的骨矿物质密度（BMD）和骨矿物质含量（BMC）高于白色儿童。我们研究了胰岛素样生长因子（IGFs）的差异是儿童时期BMD的重要决定因素这一假设。方法：我们测量了59名非裔美国人和59名白色女孩的IGF和IGF结合蛋白，这些女孩的年龄、体重指数、社会经济状况和青春期阶段相匹配。采用双发射X线骨密度仪测定BMD和BMC。结果非裔美国女孩的总BMD（P <.001）、BMC（P <.01）、总IGF-1（P <.001）和游离IGF-1（P <.01）高于白色女孩。IGFBP-1、IGFBP-2和IGFBP-3在两组中相似，或在非裔美国人中较低。在白色女孩中，IGF-1与IGF-2呈正相关（P =.012），但在非裔美国人中，IGF-1与IGF-2呈负相关（P =.015）。IGF-1和游离IGF-1与BMD/BMC呈正相关。多元回归分析显示，BMC中80%的方差可以通过模型中的体重、身高和IGF-1来解释。当IGF-1作为一个因素被纳入时，种族并没有增加模型的预测能力。结论非裔美国女孩的IGF-1和游离IGF-1水平高于白色女孩，这可能与非裔美国女孩BMD增高有关。
OBJECTIVES African American children have greater bone mineral density (BMD) and bone mineral content (BMC) than white children. We examined the hypothesis that differences in insulin-like growth factors (IGFs) are important determinants of BMD during childhood. METHODS We measured IGFs and IGF binding proteins in 59 African American and 59 white girls matched for age, body mass index, socioeconomic status, and pubertal stage. BMD and BMC were determined by dual emission x-ray absorptiometry. RESULTS African American girls had greater total BMD (P <.001), BMC (P <.01), total IGF-1 (P <.001), and free IGF-1 (P <.01) than white girls. IGFBP-1, IGFBP-2, and IGFBP-3 were similar in both groups or lower in African Americans. IGF-1 was positively correlated with IGF-2 in white girls (P =.012) but was negatively correlated with IGF-2 in African Americans (P =.015). IGF-1 and free IGF-1 were positively correlated with BMD/BMC. Multiple regression analyses showed 80% of the variance in BMC could be accounted for by the use of body weight, height, and IGF-1 in the model. When IGF-1 was included as a factor, race did not add to the model's predictive power. CONCLUSION IGF-1 and free IGF-1 are greater in African American than in white girls and may contribute to the greater BMD of African Americans.