Use of the Short Physical Performance Battery Score to Predict Loss of Ability to Walk 400 Meters: Analysis From the InCHIANTI Study
Use of the Short Physical Performance Battery Score to Predict Loss of Ability to Walk 400 Meters: Analysis From the InCHIANTI Study
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DOI：
10.1093/gerona/gln022
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发表时间：
2009-02-01
影响因子：
5.1
通讯作者：
Guralnik, Jack M.
中科院分区：
文献类型：
--
作者：
Vasunilashorn, Sarinnapha;Coppin, Antonia K.;Guralnik, Jack M.
背景早期发现行动不便仍然是预防行动不便的一个重要目标。本研究的目的是检查短体力活动成套测验（SPPB）与400 m步行能力丧失之间的相关性，这是一种越来越多地用于临床试验的客观评估的活动结果。研究样本包括来自InCHIANTI（“Invecchiare in Chianti”，Chianti地区的老龄化）研究的542名65岁及以上的成年人，他们在基线时完成了400 m步行，并在基线和3年随访时对SPPB和400 m步行进行了评价。采用多元逻辑回归模型来确定SPPB评分是否能预测基线时能够行走400 m的患者在随访时丧失行走400 m的能力。3年400 m步行失败率为15.5%。在调整了年龄、性别、教育程度、体重指数、简易精神状态检查、医疗条件数量和基线400 m步行步态速度后，SPPB评分与3年后400 m步行能力丧失显著相关。基线时SPPB评分为10分或更低的参与者在随访时活动障碍的几率明显更高（比值比[ OR] = 3.38，95%置信区间[ CI]：1.32-8.65）与评分12的患者相比，在SPPB评分范围内有分级反应（SPPB = 7、SPPB = 8、SPPB = 9的OR = 26.93，95%CI：7.51-96.50; OR = 7.67，95%CI：2.26-26.04; OR = 8.28，95%CI：3.32-20.67）。SPPB强烈预测丧失行走400米的能力。因此，使用SPPB来识别下半身功能受限的高风险老年人，似乎是识别将从预防性干预措施中受益最多的个人的有效手段。
Background. Early detection of mobility limitations remains an important goal for preventing mobility disability. The purpose of this study was to examine the association between the Short Physical Performance Battery (SPPB) and the loss of ability to walk 400 m, an objectively assessed mobility outcome increasingly used in clinical trials.Methods. The study sample consisted of 542 adults from the InCHIANTI ("Invecchiare in Chianti," aging in Chianti area) study aged 65 and older, who completed the 400 m walk at baseline and had evaluations on the SPPB and 400 m walk at baseline and 3-year follow-up. Multiple logistic regression models were used to determine whether SPPB scores predict the loss of ability to walk 400 m at follow-up among persons able to walk 400 m at baseline.Results. The 3-year incidence of failing the 400 m walk was 15.5%. After adjusting for age, sex, education, body mass index, Mini-Mental State Examination, number of medical conditions, and 400 m walk gait speed at baseline, SPPB score was significantly associated with loss of ability to walk 400 m after 3 years. Participants with SPPB scores of 10 or lower at baseline had significantly higher odds of mobility disability at follow-up ( odds ratio [ OR] = 3.38, 95% confidence interval [ CI]: 1.32-8.65) compared with those who scored 12, with a graded response across the range of SPPB scores ( OR = 26.93, 95% CI: 7.51-96.50; OR = 7.67, 95% CI: 2.26-26.04; OR = 8.28, 95% CI: 3.32-20.67 for SPPB = 7, SPPB 8, and SPPB 9, respectively).Conclusions. The SPPB strongly predicts loss of ability to walk 400 m. Thus, using the SPPB to identify older persons at high risk of lower body functional limitations seems a valid means of recognizing individuals who would benefit most from preventive interventions.