Temporal lobectomy in congenital porencephaly associated with hippocampal sclerosis
Temporal lobectomy in congenital porencephaly associated with hippocampal sclerosis
复制标题
DOI：
10.1001/archneur.60.6.830
复制
发表时间：
2003-06-01
影响因子：
--
通讯作者：
Kuzniecky, R
中科院分区：
文献类型：
--
作者：
Burneo, JG;Faught, E;Kuzniecky, R
背景：癫痫并发颞外孔颅畸形和海马硬化患者的临床和神经影像学特征已有报道。目的：探讨6例顽固性癫痫并发颞外孔颅畸形和海马硬化的临床特点及手术效果。患者与方法：对24例脑孔畸形合并癫痫患者进行研究。其中6例在颞区有致痫灶。所有患者均接受视频脑电图监测、磁共振成像研究和神经心理学评估。在颞叶癫痫患者亚群中，1例患者行颅内脑电图监测。5例患者行颞叶切除术。使用Engel分类评估结果。结果：所有患者均获得癫痫发作的自由。切除组织的病理分析证实了手术前诊断为内侧颞叶硬化。结论：颞外孔颅畸形合并难治性癫痫的患者应及早评估，如果临床、磁共振成像和脑电图结果支持颞叶发作性癫痫的诊断，应考虑颞叶切除术。
Background: Clinical and neuroimaging features of patients with epilepsy and coexisting extratemporal porencephaly and hippocampal sclerosis have been previously described.Objective: To present the clinical characteristics and surgical outcome of 6 patients with intractable epilepsy and coexisting extratemporal porencephaly and hippocampal sclerosis.Patients and Methods: Twenty-four patients with porencephaly and epilepsy were studied. Of these, 6 had an epileptogenic focus in the temporal region. All patients underwent video electroencephalogram monitoring, magnetic resonance imaging studies, and neuropsychological evaluation. Of the subset of patients with temporal lobe epilepsy, I patient underwent intracranial electroencephalogram monitoring. Temporal lobe resection was performed in 5 patients. Outcomes were evaluated using the Engel classification.Results: Freedom from seizures was achieved in all patients. Pathologic analysis of the resected tissue confirmed the presurgical diagnosis of mesial temporal sclerosis.Conclusion: Patients with extratemporal porencephaly and intractable seizures should be evaluated early and be considered for temporal lobectomy if clinical, magnetic resonance imaging, and electroencephalogram findings support the diagnosis of temporal lobe onset seizures.