Inflammatory Measures in Depressed Patients With and Without a History of Adverse Childhood Experiences
Inflammatory Measures in Depressed Patients With and Without a History of Adverse Childhood Experiences
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DOI：
10.3389/fpsyt.2018.00610
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发表时间：
2018-11-27
影响因子：
4.7
通讯作者：
Kuehl, Linn K.
中科院分区：
文献类型：
--
作者：
de Punder, Karin;Entringer, Sonja;Kuehl, Linn K.
背景：重性抑郁障碍（MDD）是一种复杂的精神疾病，有不同的亚型和病因。暴露于不良童年经历（ACE）是MDD在以后生活中发展的重要风险因素。有证据表明，促炎过程可能会传递这种风险，因为MDD和ACE都与炎症水平增加有关。在本研究中，我们的目的是解开MDD和ACE对炎症水平的影响。方法：炎症标志物在23名患有ACE的MDD患者、23名没有ACE的MDD患者、21名患有ACE的健康参与者、和21例无ACE的健康受试者（平均年龄：35 ± 11（SD）岁）。没有患者和参与者服用精神药物。ACE进行了评估与早期创伤量表（ETI），并被定义为中度至重度暴露于性或身体abuse.Results：组的差异，观察不同的炎症措施。与健康对照相比，患有ACE的MDD患者显示出显著更高的IL-6浓度（p = 0.018）、更高的WBC计数（p = 0.003）和增加的全身炎症水平，如CIS（p = 0.003）所示。相比之下，没有ACE的MDD患者表现出类似的炎症水平的对照组（p = 0.93）。结论：我们观察到升高的炎症在MDD患者的ACE史，这可能表明一个亚型的“炎症性抑郁症”。因此，ACE的MDD患者可能从抗炎治疗中获益。
Background: Major depressive disorder (MDD) is a complex psychiatric condition with different subtypes and etiologies. Exposure to adverse childhood experiences (ACE) is an important risk factor for the development of MDD later in life. Evidence suggests that pro-inflammatory processes may convey this risk as both MDD and ACE have been related to increased levels of inflammation. In the present study, we aimed to disentangle the effects of MDD and ACE on inflammation levels.Methods: Markers of inflammation (plasma interleukin(IL)-6 and high sensitive C-reactive protein (hsCRP) concentrations, white blood cell (WBC) count and a composite inflammation score (CIS) combining all three) were assessed in 23 MDD patients with ACE, 23 MDD patients without ACE, 21 healthy participants with ACE, and 21 healthy participants without ACE (mean age: 35 +/- 11 (SD) years). None of the patients and participants was taking psychotropic medication. ACE was assessed with the Early Trauma Inventory (ETI) and was defined as moderate to severe exposure to sexual or physical abuse.Results: Group differences in the different inflammatory measures were observed. MDD patients with ACE showed significantly higher IL-6 concentrations (p = 0.018), higher WBC counts (p = 0.003) and increased general inflammation levels as indicated by the CIS (p = 0.003) compared to healthy controls. In contrast, MDD patients without ACE displayed similar inflammation levels to the control group (p = 0.93).Conclusion: We observed elevated inflammation in MDD patients with a history of ACE, which could indicate a subtype of "inflammatory depression". Accordingly, MDD patients with ACE might potentially benefit from anti-inflammatory therapies.