A comparison of pre- and post-surgical administration of bupivacaine or buprenorphine following laparotomy in the rat
A comparison of pre- and post-surgical administration of bupivacaine or buprenorphine following laparotomy in the rat
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DOI：
10.1258/002367799780578534
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发表时间：
1999-01-01
影响因子：
2.4
通讯作者：
Flecknell, PA
中科院分区：
文献类型：
--
作者：
Hayes, JH;Flecknell, PA
在大鼠剖腹手术模型中研究了布比卡因（一种长效局部麻醉剂）和丁丙诺啡（一种阿片类镇痛剂）在术前或术后给药的作用。手术麻醉诱导和维持氟烷。镇痛治疗的类型是手术后体重和食物及水摄入量减少的重要因素。在布比卡因给药组和未接受镇痛剂的动物中观察到最大降幅。镇痛药的给药时间对布比卡因给药的效果没有影响。在手术前接受丁丙诺啡的组在食物摄入方面表现出比手术结束时接受丁丙诺啡的组更少的抑郁。接受丁丙诺啡的动物比接受盐水或布比卡因的动物表现出更少的活动抑制。
The effects of bupivacaine, a long-acting local anaesthetic, and buprenorphine, an opioid analgesic, administered either pre- or post-operatively, were investigated in a rat laparotomy model. Surgical anaesthesia was induced and maintained with halothane. The type of analgesic treatment was a significant factor in the reduction in body weight and food and water intake which occurred following surgery. The largest reductions were seen in the bupivacaine-treated groups and those animals which received no analgesics. The timing of administration of analgesics had no influence on the effect of bupivacaine administration. The group receiving buprenorphine before surgery showed less depression in food intake than the group receiving buprenorphine at the end of surgery. Animals which received buprenorphine showed less depression of activity than these receiving saline or bupivacaine.