A Pericyte Origin of Spinal Cord Scar Tissue
A Pericyte Origin of Spinal Cord Scar Tissue
复制标题
DOI：
10.1126/science.1203165
复制
发表时间：
2011-07-08
期刊：
影响因子：
56.9
通讯作者：
Frisen, Jonas
中科院分区：
文献类型：
--
作者：
Goritz, Christian;Dias, David O.;Frisen, Jonas
在中枢神经系统损伤后，丢失的组织再生有限，并且损伤被疤痕封闭。瘢痕的作用是复杂的，并且已经讨论了超过世纪，瘢痕通常被称为胶质瘢痕，因为其富含星形胶质细胞。在这里，我们表明，一个特定的周细胞亚型引起瘢痕形成的基质细胞，数量超过星形胶质细胞，在受伤的脊髓。阻断这种周细胞亚型的后代产生会导致无法封闭受损组织。结缔组织的形成在许多损伤和病理中是常见的，在这里我们展示了纤维化的细胞起源。
There is limited regeneration of lost tissue after central nervous system injury, and the lesion is sealed with a scar. The role of the scar, which often is referred to as the glial scar because of its abundance of astrocytes, is complex and has been discussed for more than a century. Here we show that a specific pericyte subtype gives rise to scar-forming stromal cells, which outnumber astrocytes, in the injured spinal cord. Blocking the generation of progeny by this pericyte subtype results in failure to seal the injured tissue. The formation of connective tissue is common to many injuries and pathologies, and here we demonstrate a cellular origin of fibrosis.