CD19+CD1d+CD5+ B cell frequencies are increased in patients with tuberculosis and suppress Th17 responses
CD19+CD1d+CD5+ B cell frequencies are increased in patients with tuberculosis and suppress Th17 responses
复制标题
结核病患者中 CD19( )CD1d( )CD5( ) B 细胞频率增加并抑制 Th17 反应。
DOI：
10.1016/j.cellimm.2012.01.007
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发表时间：
2012-01-01
影响因子：
4.3
通讯作者：
Chen, Xinchun
中科院分区：
文献类型：
--
作者：
Zhang, Mingxia;Zheng, Xuebao;Chen, Xinchun
虽然B细胞在结核分枝杆菌感染后宿主免疫反应中的重要性已被认识到，但B细胞的决定性作用尚未确定。在本研究中，我们发现从结核病患者中分离的原代CD19(+) B细胞显著抑制Th17细胞的活化，但不抑制Th1细胞的活化。此外，抑制活性是由CD19(+)CD1d(+)CO5(+) B细胞群介导的。值得注意的是，与健康供者的CD19(+)CD1d(+)CD5(+) B细胞相比，结核病患者的CD19(+)CD1d(+)CD5(+) B细胞的抑制活性明显更高。此外，结核病患者外周血中CD19(+)CD1d(+)CD5(+) B细胞的频率与Th17细胞的频率呈负相关。B细胞负调控Th17应答的发现，为结核分枝杆菌感染期间除调节性T细胞外调控CD4(+) T细胞应答提供了一种新机制，可能影响结核病的临床结果。(C) 2012爱思唯尔公司版权所有。
Although the importance of B cells in the host immune response upon Mycobacterium tuberculosis infection has been recognized, a conclusive role for B cells has yet to be determined. In the present study, we found that primary CD19(+) B cells isolated from patients with tuberculosis significantly inhibited Th17, but not Th1, cell activation. Moreover, the suppressive activity was mediated by a CD19(+)CD1d(+)CO5(+) B cell population. Notably, patients with tuberculosis were found to have significantly higher frequencies of CD19(+)CD1d(+)CD5(+) B cells with stronger suppressive activity than such cells from healthy donors. Furthermore, the frequency of CD19(+)CD1d(+)CD5(+) B cells in peripheral blood was inversely correlated with that of Th17 cells in patients with tuberculosis. This finding that B cells negatively regulate Th17 responses provides a novel mechanism in the regulation of CD4(+) T cell responses aside from regulatory T cells during M. tuberculosis infection, which may impact the clinical outcome of tuberculosis. (C) 2012 Elsevier Inc. All rights reserved.