Interferon‐α suppressed granulocyte colony stimulating factor production is reversed by CL097, a TLR7/8 agonist
Interferon‐α suppressed granulocyte colony stimulating factor production is reversed by CL097, a TLR7/8 agonist
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TLR7/8 激动剂 CL097 可逆转干扰素 α 抑制的粒细胞集落刺激因子产生
DOI：
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发表时间：
2010
影响因子：
4.1
通讯作者：
C. O’Farrelly
中科院分区：
文献类型：
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作者：
T. Tajuddin;E. Ryan;S. Norris;J. Hegarty;C. O’Farrelly
Background and Aim: Neutropenia, a major side‐effect of interferon‐α (IFN‐α) therapy can be effectively treated by the recombinant form of granulocyte colony stimulating factor (G‐CSF), an important growth factor for neutrophils. We hypothesized that IFN‐α might suppress G‐CSF production by peripheral blood mononuclear cells (PBMCs), contributing to the development of neutropenia, and that a toll‐like receptor (TLR) agonist might overcome this suppression.
影响因子：
20.3
作者：
Hirbe, Angela C.;Uluckan, Ozge;Weilbaecher, Katherine
通讯作者：
Weilbaecher, Katherine
影响因子：
2.1
作者：
Chakraborty, Arup;Guha, Sushovan
通讯作者：
Guha, Sushovan