Developmental expression of the N-myc downstream regulated gene (Ndrg) family during Xenopus tropicalis embryogenesis.
Developmental expression of the N-myc downstream regulated gene (Ndrg) family during Xenopus tropicalis embryogenesis.
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DOI：
10.1387/ijdb.150178xh
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发表时间：
2015
期刊：
影响因子：
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通讯作者：
Chao Zhong;Yan-Kuan Zhou;Shan-shan Yang;Jun-Fang Zhao;Xiao-long Zhu;Hen-Huang Chen;Peichao Chen;Liquan Huang;Xiao Huang
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文献类型：
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作者：
Chao Zhong;Yan-Kuan Zhou;Shan-shan Yang;Jun-Fang Zhao;Xiao-long Zhu;Hen-Huang Chen;Peichao Chen;Liquan Huang;Xiao Huang
N-myc下游调节基因（Ndrg）家族由四个主要成员Ndrg 1、2、3和4组成。Ndrg基因参与许多重要的生物学事件，包括发育。然而，该基因家族在脊椎动物胚胎发生过程中的全面表达模式仍然是未知的。在这里，我们从进化的角度分析了Ndrg家族，并研究了热带爪蟾胚胎发生过程中Ndrg基因的表达模式。脊椎动物的不同Ndrg家族成员被分成不同的同源簇，这些同源簇可以进一步分为两个组，并且每个Ndrg家族成员在进化过程中都是很保守的。在热带爪蟾早期发育过程中，Ndrg 1、2、3和4的时空表达模式不同。Ndrg 1、2和4是母系表达基因，而Ndrg 3是合子表达基因。Ndrg基因在发育中的中枢神经系统、发育中的感觉器官和发育中的排泄器官中差异表达。此外，它们还显示了其他特异性表达结构域。我们的研究结果表明，Ndrg基因表现出特定的表达模式，并可能在脊椎动物胚胎发育过程中发挥不同的作用。
The N-myc downstream regulated gene (Ndrg) family consists of four main members Ndrg1, 2, 3, and 4. The Ndrg genes are involved in many vital biological events including development. However, comprehensive expression patterns of this gene family during vertebrate embryogenesis remain largely unknown. Here, we analyzed the Ndrg family from the evolutionary perspective and examined the expression patterns of the Ndrg genes during Xenopus tropicalis embryogenesis. Different Ndrg family members of vertebrates are separated into different homology clusters which can be further classified into two groups and each Ndrg family member is well conserved during evolution. The temporal and spatial expression patterns of Ndrg1, 2, 3 and 4 are different during early Xenopus tropicalis development. Ndrg1, 2 and 4 are maternally expressed genes while Ndrg3 is a zygotically expressed gene. The Ndrg genes are differentially expressed in the developing central nervous system, the developing sensory organs, and the developing excretory organs. Moreover, they also show other specific expression domains. Our results indicate that the Ndrg genes exhibit specific expression patterns and may play different roles during vertebrate embryogenesis.