Developmental effects of aggressive behavior in male adolescents assessed with structural and functional brain imaging.
Developmental effects of aggressive behavior in male adolescents assessed with structural and functional brain imaging.
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DOI：
10.1093/scan/nsp036
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发表时间：
2011
影响因子：
4.2
通讯作者：
Maren Strenziok;F. Krueger;A. Heinecke;R. Lenroot;K. Knutson;Elke van der Meer;J. Grafman
中科院分区：
文献类型：
--
作者：
Maren Strenziok;F. Krueger;A. Heinecke;R. Lenroot;K. Knutson;Elke van der Meer;J. Grafman
攻击性行为在青春期很常见。尽管在成人中已经报道了与攻击相关的前额叶皮质(VmPFC)和额叶皮质(FPC)的功能变化，但青少年攻击行为的神经相关性尚不清楚，特别是在结构性神经发育的背景下。我们使用功能和结构磁共振成像(MRI)来测量血氧水平依赖的信号和皮质厚度。在一项分组设计的实验中，14-17岁的青少年想象与同龄人进行攻击性和非攻击性互动。我们发现，随着年龄的增长，FPC中vmPFC的激活减少与想象的攻击行为有关，以及与攻击相关的激活和皮质变薄。FPC激活的变化也与对攻击行为严重程度的判断有关。VmPFC激活减少与更大的攻击性有关，表明其正常功能是对攻击冲动实施抑制性控制。同时激活FPC可能反映了对攻击性行为造成的有害后果的预见。年龄依赖的激活变化与皮质变薄的相关性表明，在青春期，FPC正在走向成熟，走向社会和认知信息处理的精细化，这可能有助于在攻击性环境中的成熟社会行为。
Aggressive behavior is common during adolescence. Although aggression-related functional changes in the ventromedial prefrontal cortex (vmPFC) and frontopolar cortex (FPC) have been reported in adults, the neural correlates of aggressive behavior in adolescents, particularly in the context of structural neurodevelopment, are obscure. We used functional and structural magnetic resonance imaging (MRI) to measure the blood oxygenation level-depended signal and cortical thickness. In a block-designed experiment, 14-17-year old adolescents imagined aggressive and non-aggressive interactions with a peer. We show reduced vmPFC activation associated with imagined aggressive behavior as well as enhanced aggression-related activation and cortical thinning in the FPC with increasing age. Changes in FPC activation were also associated with judgments of the severity of aggressive acts. Reduced vmPFC activation was associated with greater aggression indicating its normal function is to exert inhibitory control over aggressive impulses. Concurrent FPC activation likely reflects foresight of harmful consequences that result from aggressive acts. The correlation of age-dependent activation changes and cortical thinning demonstrates ongoing maturation of the FPC during adolescence towards a refinement of social and cognitive information processing that can potentially facilitate mature social behavior in aggressive contexts.