Hormonal and environmental factors in the pathogenesis of BB rat diabetes.
Hormonal and environmental factors in the pathogenesis of BB rat diabetes.
复制标题
BB 大鼠糖尿病发病机制中的激素和环境因素。
DOI：
10.1016/s0026-0495(83)80008-0
复制
发表时间：
1983
期刊：
影响因子：
--
通讯作者：
Like,AA
中科院分区：
文献类型：
--
作者：
Rossini,AA;Mordes,JP;Gallina,DL;Like,AA
研究了以下激素和环境因素在BB大鼠糖尿病发病机制中的作用：垂体切除术、去势、迷走神经切断术、抗β细胞毒素保护剂和应激。这些因素都没有改变糖尿病的发病率。因此，它们不太可能作为BB大鼠糖尿病的引发剂或促进剂。这些阴性结果是对先前报告感染或饮食对BB糖尿病无影响的研究的补充。到目前为止，没有激素或环境因素已被确定，改变发病率的disbets在这个动物模型。
The role of the following hormonal and environmental factors in the pathogenesis of diabetes in the BB rat was studied: hypophysectomy, castration, vagotomy, agents protective against beta cytotoxins, and stress. None of these factors altered the incidence of diabetes. They are thus unlikely to act as initiators or promoters of BB rat diabetes. These negative findings are complementary to previous studies reporting no influence of infection or diet on BB diabetes. To date, no hormonal or environmental factors have been identified that alter the incidence of disbetes in this animal model.