Serum insulin concentrations in daily drinkers compared with abstainers in the New Mexico elder health survey.
Serum insulin concentrations in daily drinkers compared with abstainers in the New Mexico elder health survey.
复制标题
新墨西哥州老年人健康调查中，每日饮酒者与戒酒者的血清胰岛素浓度进行了比较。
DOI：
10.1093/gerona/58.10.m960
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发表时间：
2003
期刊：
影响因子：
--
通讯作者：
Garry,PhilipJ
中科院分区：
文献类型：
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作者：
Kenkre,PrabhavV;Lindeman,RobertD;LillianYau,C;Baumgartner,RichardN;Garry,PhilipJ
背景：最近的流行病学研究表明，经常饮酒的人比不饮酒的人糖尿病患病率更低。这项研究的目的是比较日常饮酒者和戒酒者(糖尿病、糖耐量受损和正常糖耐量的参与者)的血糖和胰岛素浓度，以确定是否存在葡萄糖敏感性(抵抗力)的差异，这可能解释饮酒者中糖尿病患病率较低的原因。方法：随机选择883名西班牙裔和非西班牙裔白人男性和女性，年龄65岁，在一家高级健康诊所接受家庭访谈和4小时访谈/检查(新墨西哥州老年人健康调查)，进行横断面社区调查。这些访谈包括饮酒频率、类型和数量的历史记录。在隔夜禁食后和摄入75克葡萄糖后2小时采集血清样本，以测定血糖和胰岛素水平。测量身高和体重以确定体重指数。结果：每天饮酒的参与者与不饮酒的参与者相比，空腹和糖后2小时血清胰岛素浓度显著降低，当使用线性Logistic回归模型调整血糖浓度、性别、种族、年龄和体重指数时。结论：相对高胰岛素血症的禁酒者似乎比每天适度饮酒的人更容易出现胰岛素抵抗。这种胰岛素敏感性的差异可能解释了在各种流行病学研究中观察到的饮酒者与戒酒者相比糖尿病患病率较低的原因。
Background.Recent epidemiological studies have shown that individuals who ingest alcohol regularly have a lower prevalence of diabetes mellitus than those who abstain. The purpose of this study was to compare serum glucose and insulin concentrations between daily drinkers and abstainers stratified by diabetic status (participants with diabetes, impaired glucose tolerance, and normal glucose tolerance) to determine if there was a difference in glucose sensitivity (resistance) that might explain the lower prevalence of diabetes in drinkers.Methods.A cross-sectional community survey was conducted of 883 randomly selected Hispanic and non-Hispanic white men and women, aged ≥ 65 years, undergoing a home interview and 4-hour interview/examination in a senior health clinic (The New Mexico Elder Health Survey). The interviews included a history of frequency, type, and quantity of alcohol ingested. Serum samples were obtained after an overnight fast and 2 hours after ingestion of 75 grams of glucose for determination of glucose and insulin levels. Height and weight was measured for determination of body mass index.Results.Participants who consumed alcohol daily had significantly lower fasting and 2-hour postglucose serum insulin concentrations compared with those who abstained from alcohol intake, when adjusted using linear logistic regression models for serum glucose concentration, gender, ethnicity, age, and body mass index.Conclusions.Abstainers with their relative hyperinsulinemia appear to be more insulin resistant than daily moderate drinkers. This difference in insulin sensitivity may explain the lower prevalence of diabetes in drinkers compared with abstainers observed in various epidemiological studies.