Oxidative iodination of deactivated arenes in concentrated sulfuric acid with I2/NaIO4 and KI/NaIO4 iodinating systems
Oxidative iodination of deactivated arenes in concentrated sulfuric acid with I2/NaIO4 and KI/NaIO4 iodinating systems
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DOI：
10.1055/s-2006-926374
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发表时间：
2006-04-04
影响因子：
2.6
通讯作者：
Skulski, L
中科院分区：
文献类型：
--
作者：
Kraszkiewicz, L;Sosnowski, M;Skulski, L
失活芳烃用强亲电I+试剂单碘化或二碘化，这些试剂由NaIO4和I-2或KI在浓H2SO4中制备（重量至少95%）。一般情况下，使用的深棕色碘化溶液略过量（1.1/1.5等量，硝基苯需用2等量）。在25-30℃的条件下进行碘化，反应时间为1-2小时，采用“直接”或“逆”芳香碘化方法，可得到单碘化或二碘化的纯产物，优化收率为31- 91%。
Deactivated arenes were mono- or diiodinated with strong electrophilic I+ reagents, which were prepared from NaIO4 and either I-2 or KI in concentrated H2SO4 (minimum 95% by weight). In general a small excess of the dark brown iodinating solution was used (1.1/1.5 equivalents, for nitrobenzene two equivalents was required). The iodinations were conducted at 25-30 degrees C with a reaction time of 1-2 hours Using either a 'direct' or an 'inverse' method of aromatic iodination to give mono- or diiodinated pure products in 31-91 % optimized yields.