Association between sleep duration and hemoglobin A1c level
Association between sleep duration and hemoglobin A1c level
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DOI：
10.1016/j.sleep.2007.07.017
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发表时间：
2008-10-01
期刊：
影响因子：
4.8
通讯作者：
Ohida, Takashi
中科院分区：
文献类型：
--
作者：
Nakajima, Hiromi;Kaneita, Yoshitaka;Ohida, Takashi
目的：睡眠习惯与血红蛋白 A(1c) (HbA(1c)) 水平之间的关联尚未得到充分研究。在本次针对当地社区居民的研究中，研究了睡眠时间与 HbA(1c) 水平之间的关联。方法：向日本农村社区的 1062 名居民邮寄自填问卷，并收集填写完毕的问卷。采集时，使用外周血样本测量空腹血糖和 HbA(1c) 水平。对于分析，被认为代表高水平的值为空腹血糖水平 >= 126 mg/dl 和 HbA(1c) 水平 >= 6.5%。进行逻辑回归分析以检查睡眠时间与高空腹血糖或高 HbA(1c) 水平之间的关联。 结果：在睡眠时间短或长的受试者中，高空腹血糖和高 HbA(1c) 水平的患病率显着较高 (p < 0.01)。 Logistic 回归分析表明，高 HbA(1c) 水平与睡眠持续时间之间存在显着关联。高 HbA(1c) 水平的调整优势比在短睡眠时间和长睡眠时间方面均显示出较高的值。结论：HbA(1c) 水平与睡眠时间呈 U 形关联。这些结果表明，患有葡萄糖耐量障碍的个体可能存在适当的睡眠持续时间范围。预计目前的发现将有助于糖尿病的治疗和预防。 (C) 2007 Elsevier B.V. 保留所有权利。
Objective: The association between sleep habits and hemoglobin A(1c) (HbA(1c)) level has not been sufficiently examined. In the present study of residents in a local community, the associations between sleep duration and HbA(1c) level were examined.Methods: Self-administered questionnaires were mailed to 1062 residents in a rural community in Japan, and completed questionnaires were collected. At the time of collection, the fasting plasma glucose and HbA(1c) levels were measured using peripheral blood samples. For the analyses, values that were considered to represent high levels were a fasting plasma glucose level of >= 126 mg/dl and a HbA(1c) level of >= 6.5%. Logistic regression analyses were performed to examine the associations between sleep duration and high fasting plasma glucose or high HbA(1c), levels.Results: The prevalence of high fasting plasma glucose and high HbA(1c) levels was significantly high (p < 0.01) in subjects with a short or a long sleep duration. Logistic regression analyses demonstrated a significant association between high HbA(1c) level and sleep duration. The adjusted odds ratios for a high HbA(1c) level showed high values with regard to both short and long sleep durations.Conclusions: HbA(1c) level showed a U-shaped association with sleep duration. These results suggest that there may be an appropriate range of sleep duration in individuals with glucose tolerance disorders. It is expected that the present findings will contribute to the treatment and prevention of diabetes mellitus. (C) 2007 Elsevier B.V. All rights reserved.