Perfluoroalkyl chemicals and elevated serum uric acid in US adults.
Perfluoroalkyl chemicals and elevated serum uric acid in US adults.
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DOI：
10.2147/clep.s21677
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发表时间：
2011
影响因子：
3.9
通讯作者：
Ducatman A
中科院分区：
文献类型：
--
作者：
Shankar A;Xiao J;Ducatman A
全氟烷基化学品，包括全氟辛酸和全氟辛烷磺酸，是一种人造化学品，已在超过98%的美国人口的血液中检测到。血清尿酸是一种新的生物标志物，其即使轻微升高也与高血压、糖尿病、心血管疾病和慢性肾脏疾病的发展有关。我们研究了血清中全氟烷基化学物质（包括全氟辛酸和全氟辛烷磺酸）与美国成年人代表性样本中尿酸水平升高的关系。我们检查了1999-2000年和2003-2006年国家健康和营养检查调查的3883名参与者，这是一项代表性的，多种族的非制度化美国成年人人口调查。以四分位数分析血清全氟辛酸和全氟辛烷磺酸。主要结局为高尿酸血症。我们发现，血清中全氟烷基化合物的水平，包括全氟辛酸和全氟辛烷磺酸，与高尿酸血症呈正相关。这种关联似乎与年龄、性别、种族、体重指数、糖尿病、高血压和血清胆固醇等混杂因素无关。与四分位数1的受试者（参照）相比，四分位数4的受试者中全氟辛酸和全氟辛烷磺酸的高尿酸血症多变量比值比分别为1.97（95%置信区间1.44-2.70，P < 0.0001）和1.48%（95%置信区间0.99-2.22，P = 0.0433）。这种观察到的相关性在按性别和体重指数进行的亚组分析中持续存在。我们的研究结果表明，即使在美国普通人群中全氟烷基化学品暴露水平较低的情况下，全氟烷基化学品水平升高也与高尿酸血症相关。
Perfluoroalkyl chemicals, including perfluorooctanoic acid and perfluorooctane sulfonate, are man-made chemicals that have been detected in the blood of over 98% of the US population. Serum uric acid is a novel biomarker, even mild elevations of which has been implicated in the development of hypertension, diabetes mellitus, cardiovascular disease, and chronic kidney disease. We examined the relationship of serum perfluoroalkyl chemicals, including perfluorooctanoic acid and perfluorooctane sulfonate, and elevated uric acid levels in a representative sample of US adults. We examined 3883 participants from the 1999–2000 and 2003–2006 National Health and Nutritional Examination Surveys, a representative, multiethnic population-based survey of noninstitutionalized US adults. Serum perfluorooctanoic acid and perfluorooctane sulfonate were analyzed as quartiles. The main outcome was hyperuricemia. We found that serum levels of perfluoroalkyl chemicals, including perfluorooctanoic acid and perfluorooctane sulfonate, were positively associated with hyperuricemia. This association appeared to be independent of confounders such as age, gender, race-ethnicity, body mass index, diabetes, hypertension, and serum cholesterol. Compared with subjects in quartile 1 (referent), the multivariate odds ratio for hyperuricemia among subjects in quartile 4 was 1.97 (95% confidence interval 1.44–2.70, P < 0.0001) for perfluorooctanoic acid and 1.48% (95% confidence interval 0.99–2.22, P = 0.0433) for perfluorooctane sulfonate. This observed association persisted in subgroup analysis by gender and body mass index. Our results demonstrate that elevated levels of perfluoroalkyl chemicals are associated with hyperuricemia even at low perfluoroalkyl chemical exposure levels as seen in the US general population.