Different dose regimes and administration methods of tranexamic acid in cardiac surgery: a meta-analysis of randomized trials
Different dose regimes and administration methods of tranexamic acid in cardiac surgery: a meta-analysis of randomized trials
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DOI：
10.1186/s12871-019-0772-0
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发表时间：
2019-07-15
影响因子：
2.2
通讯作者：
Shi, Jia
中科院分区：
文献类型：
--
作者：
Guo, Jingfei;Gao, Xurong;Shi, Jia
研究背景氨甲环酸（TXA）减少心脏手术围术期失血量和异体输血的疗效已被研究证实，但其不良反应尤其是癫痫发作一直是人们关注的问题。本荟萃分析旨在提供关于最佳剂量和给药方法的信息，这些方法有效且不良结局最少。方法我们检索了科克伦对照试验中心注册中心、MEDLINE和EMBASE，以获取2018年12月31日之前发表的所有相关文章。入选标准为接受择期心脏手术的成年患者，仅考虑比较TXA与安慰剂的随机对照试验。两名作者独立评估试验质量和提取相关data.ResultsWe纳入49项研究，10,591例患者进行分析。TXA显著降低输血率（RR 0.71，95%CI 0.65 ~ 0.78，P
BackgroundThe efficacy of tranexamic acid (TXA) to reduce perioperative blood loss and allogeneic blood transfusion in cardiac surgeries has been proved in previous studies, but its adverse effects especially seizure has always been a problem of concern. This meta-analysis aims to provide information on the optimal dosage and delivery method which is effective with the least adverse outcomes.MethodsWe searched Cochrane Central Register of Controlled Trials, MEDLINE and EMBASE for all relevant articles published before 2018/12/31. Inclusion criteria were adult patients undergoing elective heart surgeries, and only randomized control trials comparing TXA with placebo were considered. Two authors independently assessed trial quality and extracted relevant data.ResultsWe included 49 studies with 10,591 patients into analysis. TXA significantly reduced transfusion rate (RR 0.71, 95% CI 0.65 to 0.78, P