Simultaneous acquisition of high-contrast and quantitative liver T1 images using 3D phase-sensitive inversion recovery: a feasibility study
Simultaneous acquisition of high-contrast and quantitative liver T1 images using 3D phase-sensitive inversion recovery: a feasibility study
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DOI：
10.1177/0284185116678273
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发表时间：
2017-08-01
期刊：
影响因子：
1.3
通讯作者：
Ishimori, Yoshiyuki
中科院分区：
文献类型：
--
作者：
Fujiwara, Yasuhiro;Maruyama, Hirotoshi;Ishimori, Yoshiyuki
背景：慢性病肝脏图像中肿瘤与肝脏的对比度较低，因为钆基肝细胞特异性造影剂 (Gd-EOB-DTPA) 在肝细胞中的积累较少。目的：确定相敏反转恢复 (PSIR) 是否可以改善钆基造影剂和肝实质的 T-1 对比度，同时提供准确的 T-1 值 材料和方法：将使用 PSIR 获得的不同 Gd 浓度的体模的图像对比度与传统涡轮场回波 (TFE) 结果进行比较。 T-1 值是使用 PSIR 通过执行迭代来估计的，以研究两个 IR 磁化演化。使用红外自旋回波 (IR-SE) 和 Look-Locker (L-L) 序列验证估计的 T-1 值。在一项体内研究中，比较了 7 名志愿者的 PSIR 和 TFE 图像的肝脏与脾脏和肝脏与肌肉的对比度，以及使用 PSIR 和 L-L 序列获得的肝实质、脾脏和肌肉的 T-1 值。 结果：PSIR 图像显示的 T-1 对比度高于 TFE 结果中的 T-1 对比度。 PSIR 和 IR-SE T-1 值呈线性相关。此外，使用 PSIR 估计的 R-1 与使用 IR-SE 和 L-L 测量的 R-1 相关。在体内研究中，PSIR 的肝脏与脾脏以及肝脏与肌肉的对比度显着高于使用 TFE 获得的对比度。使用PSIR和L-L获得的腹部器官的T-1值明显相关。结论：当使用基于Gd的造影剂时，PSIR可能能够改善肝脏图像T-1对比度，同时产生准确的腹部器官T-1值。
Background: Tumor-to-liver contrast is low in images of chronically diseased livers because gadolinium-based hepatocyte-specific contrast agents (Gd-EOB-DTPA) accumulate less to hepatocytes.Purpose: To determine whether phase-sensitive inversion recovery (PSIR) could improve the T-1 contrasts of Gd-based contrast agents and liver parenchyma and simultaneously provide accurate T-1 values for abdominal organs.Material and Methods: The image contrasts of phantoms with different Gd concentrations that were obtained using PSIR were compared to conventional turbo field echo (TFE) results. T-1 value was estimated using PSIR by performing iterations to investigate the two IR magnetization evolutions. The estimated T-1 values were validated using IR-spin echo (IR-SE) and Look-Locker (L-L) sequences. In an invivo study, the liver-to-spleen and liver-to-muscle contrasts of the PSIR and TFE images of seven volunteers were compared, as were the T-1 values of liver parenchyma, spleen, and muscle obtained using PSIR and L-L sequences.Results: The PSIR images showed T-1 contrasts higher than those in the TFE results. The PSIR and IR-SE T-1 values were linearly correlated. Additionally, the R-1 estimated using PSIR were correlated with those measured using IR-SE and L-L. In the invivo study, the liver-to-spleen and liver-to-muscle contrasts of PSIR were significantly higher than those obtained using TFE. T-1 values of abdominal organs obtained using PSIR and L-L were clearly correlated.Conclusion: PSIR may be capable of improving liver image T-1 contrasts when Gd-based contrast agents are employed and simultaneously yielding accurate T-1 values of abdominal organs.