Quantitative X-ray phase-contrast microtomography from a compact laser-driven betatron source.
Quantitative X-ray phase-contrast microtomography from a compact laser-driven betatron source.
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DOI：
10.1038/ncomms8568
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发表时间：
2015-07-20
影响因子：
16.6
通讯作者：
Karsch S
中科院分区：
文献类型：
--
作者：
Wenz J;Schleede S;Khrennikov K;Bech M;Thibault P;Heigoldt M;Pfeiffer F;Karsch S
X射线相衬成像最近在生物医学成像、显微镜和材料科学中引发了一场分辨率和组织对比度的革命。目前，所需的高空间连贯性是由光束时间访问受限的大型同步加速器设施或通量相当有限的微聚焦X射线管提供的。由控制良好的高功率激光驱动的相对论电子辐射的X射线为这种强大的成像技术的扩散提供了一条有希望的途径。激光驱动的等离子体波加速并摆动电子，产生明亮的kev X射线发射。这种所谓的Betatron辐射是在具有良好的空间相干性和显著的光谱稳定性的准直光束中发射的。在这里，我们提出了一个生物样品的位相对比显微断层图像使用电子束管X射线。全面的源特征使重建绝对电子密度成为可能。我们的结果表明，基于激光的X射线技术为填补同步加速器和现有X射线管源之间的巨大性能差距提供了潜力。X射线相衬成像具有良好的分辨率和组织对比度，具有很大的应用前景，但光源的要求限制了它的使用。在这里，温茨等人。用高功率激光驱动的X射线辐射，显示生物样品的相衬显微断层图像。
X-ray phase-contrast imaging has recently led to a revolution in resolving power and tissue contrast in biomedical imaging, microscopy and materials science. The necessary high spatial coherence is currently provided by either large-scale synchrotron facilities with limited beamtime access or by microfocus X-ray tubes with rather limited flux. X-rays radiated by relativistic electrons driven by well-controlled high-power lasers offer a promising route to a proliferation of this powerful imaging technology. A laser-driven plasma wave accelerates and wiggles electrons, giving rise to a brilliant keV X-ray emission. This so-called betatron radiation is emitted in a collimated beam with excellent spatial coherence and remarkable spectral stability. Here we present a phase-contrast microtomogram of a biological sample using betatron X-rays. Comprehensive source characterization enables the reconstruction of absolute electron densities. Our results suggest that laser-based X-ray technology offers the potential for filling the large performance gap between synchrotron- and current X-ray tube-based sources. With excellent resolving power and tissue contrast, X-ray phase-contrast imaging holds great promise but the source requirements have limited its use. Here, Wenz et al. show a phase-contrast microtomogram of a biological sample using X-ray radiation driven by a high-power laser.