Dithiane- and trithiane-based photolabile scaffolds for molecular recognition.
Dithiane- and trithiane-based photolabile scaffolds for molecular recognition.
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用于分子识别的基于二噻烷和三噻烷的光不稳定支架。
DOI：
10.1021/ol015933u
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发表时间：
2001
期刊：
影响因子：
5.2
通讯作者：
Kutateladze,AG
中科院分区：
文献类型：
--
作者：
Mitkin,OD;Kurchan,AN;Wan,Y;Schiwal,BF;Kutateladze,AG
提出了一种具有分子识别元件的新型二硫烷基和三硫烷基光稳定分子宿主的模块化合成方法。该方法提供了一系列氨基衍生的光切割分子系统，这些分子系统能够基于氢键识别生物相关分子，例如尿素、巴比妥酸盐等。这些系统在外部（如二苯甲酮）或内部（如硝基吡啶）电子转移敏化剂的存在下进行有效的光破碎。
A modular synthetic approach to novel dithiane- and trithiane-based photolabile molecular hosts equipped with elements of molecular recognition is developed. The approach provides ready access to a family of amino-derivatized photocleavable molecular systems capable of hydrogen-bonding-based recognition of biologically relevant molecules, e.g., ureas, barbiturates etc. These systems undergo efficient photofragmentation in the presence of external (e.g., benzophenone) or internal (e.g., nitropyridine) electron-transfer sensitizers.