Superoxide release by neutrophils: synergistic effects of a phorbol ester and a calcium ionophore.
Superoxide release by neutrophils: synergistic effects of a phorbol ester and a calcium ionophore.
复制标题
中性粒细胞释放超氧化物：佛波酯和钙离子载体的协同作用。
DOI：
10.1016/s0006-291x(84)80095-9
复制
发表时间：
1984
影响因子：
3.1
通讯作者：
Karnovsky,MJ
中科院分区：
文献类型：
--
作者：
Robinson,JM;Badwey,JA;Karnovsky,ML;Karnovsky,MJ
暴露于4β-佛波醇12-肉豆蔻酸酯13-乙酸酯和钙离子载体A23187的组合次优浓度刺激豚鼠中性粒细胞向ratesca释放超氧化物。3.5-比单独加入的每种试剂引起的速率之和大一倍。这种效应在很大程度上取决于细胞外介质中钙的存在。最近的报道有关的相互作用的佛波醇酯与细胞和中性粒细胞的超氧化物释放的激活机制的数据进行了讨论。
Exposure to combined suboptimal concentrations of 4β-phorbol 12-myristate 13-acetate and the calcium ionophore A23187 stimulates superoxide release from guinea pig neutrophils to ratesca. 3.5-fold greater than the sum of the rates elicited by each of the agents added separately. This effect was largely dependent upon the presence of calcium in the extracellular medium. The data are discussed in relation to recent reports concerning the interactions of phorbol-esters with cells and the mechanism of activation of superoxide release by neutrophils.