Functional Graphene Oxide as a Nanocarrier for Controlled Loading and Targeted Delivery of Mixed Anticancer Drugs
Functional Graphene Oxide as a Nanocarrier for Controlled Loading and Targeted Delivery of Mixed Anticancer Drugs
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DOI：
10.1002/smll.200901680
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发表时间：
2010-02-22
期刊：
影响因子：
13.3
通讯作者：
Zhang, Zhijun
中科院分区：
文献类型：
--
作者：
Zhang, Liming;Xia, Jingguang;Zhang, Zhijun
报道了一种简单的制备功能性纳米氧化石墨烯（NGO）的方法，NGO是一种新型的抗癌药物纳米载体。非政府组织用磺酸基团官能化，这使其在生理溶液中稳定，随后叶酸（FA）分子与非政府组织共价结合，从而使其特异性靶向MCF-7细胞，即具有FA受体的人乳腺癌细胞。此外，两种抗癌药物，阿霉素（DOX）和喜树碱（CPT），到FA-共轭NGO（FA-NGO）通过π-π堆积和疏水相互作用的控制负载进行了研究。结果表明，FA-NGO负载两种抗癌药物显示出对MCF-7细胞的特异性靶向，并且与仅负载DOX或CPT的NGO相比具有显著高的细胞毒性。考虑到两种或更多种药物的联合使用，广泛采用的临床实践，通常显示出比单一药物更好的治疗效果，使用这些石墨烯基纳米载体的混合抗癌药物的受控负载和靶向递送可能在生物医学中找到广泛的应用。
A simple synthetic route for the preparation of functional nanoscale graphene oxide (NGO), a novel nanocarrier for the loading and targeted delivery of anticancer drugs, is reported. The NGO is functionalized with sulfonic acid groups, which render it stable in physiological solution, followed by covalent binding of folic acid (FA) molecules to the NGO, thus allowing it to specifically target MCF-7 cells, human breast cancer cells with FA receptors. Furthermore, controlled loading of two anticancer drugs, doxorubicin (DOX) and camptothecin (CPT), onto the FA-conjugated NGO (FA-NGO) via pi-pi stacking and hydrophobic interactions is investigated. It is demonstrated that FA-NGO loaded with the two anticancer drugs shows specific targeting to MCF-7 cells, and remarkably high cytotoxicity compared to NGO loaded with either DOX or CPT only. Considering that the combined use of two or more drugs, a widely adopted clinical practice, often displays much better therapeutic efficacy than that of a single drug, the controlled loading and targeted delivery of mixed anticancer drugs using these graphene-based nanocarriers may find widespread application in biomedicine.