Simpler mode of inheritance of transcriptional variation in male Drosophila melanogaster.
Simpler mode of inheritance of transcriptional variation in male Drosophila melanogaster.
复制标题
雄性果蝇转录变异遗传的更简单模式。
DOI：
10.1073/pnas.0705441104
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发表时间：
2007
影响因子：
11.1
通讯作者：
McIntyre,LaurenM
中科院分区：
文献类型：
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作者：
Wayne,MartaL;Telonis-Scott,Marina;Bono,LisaM;Harshman,Larry;Kopp,Artyom;Nuzhdin,SergeyV;McIntyre,LaurenM
性选择推动雄性更快地进化。X染色体是性选择的一个潜在的重要目标，因为雄性的半合子性允许等位基因的积累，导致两性之间的适应性权衡。X染色体的半合子性可能导致两性之间的遗传模式根本不同，男性有更多的加性变异，而女性有更多的非加性变异。事实上，我们发现转录组的遗传变异在男性中主要是加性的，而在女性中则是非加性的。正如预期的那样，这些差异在X染色体上比常染色体上更为明显，但常染色体位点也受到影响，可能是因为X连锁的转录因子。这些差异可能具有进化意义，因为可加性变异对选择反应迅速，而非可加性遗传变异则不然。因此，X染色体的半合子性可能是男性更快的转录组进化和潜在的其他表型的基础。与这一预测相一致的是，在对交配速度加快的选择做出反应的基因中，男性的加性基因和女性的非加性基因的比例过高。
Sexual selection drives faster evolution in males. The X chromosome is potentially an important target for sexual selection, because hemizygosity in males permits accumulation of alleles, causing tradeoffs in fitness between sexes. Hemizygosity of the X could cause fundamentally different modes of inheritance between the sexes, with more additive variation in males and more nonadditive variation in females. Indeed, we find that genetic variation for the transcriptome is primarily additive in males but nonadditive in females. As expected, these differences are more pronounced on the X chromosome than the autosomes, but autosomal loci are also affected, possibly because of X-linked transcription factors. These differences may be of evolutionary significance because additive variation responds quickly to selection, whereas nonadditive genetic variation does not. Thus, hemizygosity of the X may underlie much of the faster male evolution of the transcriptome and potentially other phenotypes. Consistent with this prediction, genes that are additive in males and nonadditive in females are overrepresented among genes responding to selection for increased mating speed.