Tunable iridium catalyst designs with bidentate N-heterocyclic carbene ligands for SABRE hyperpolarization of sterically hindered substrates
Tunable iridium catalyst designs with bidentate N-heterocyclic carbene ligands for SABRE hyperpolarization of sterically hindered substrates
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具有二齿N-杂环卡宾配体的可调谐铱催化剂设计，用于空间位阻基底的SABRE超极化
DOI：
10.1039/d0cc06840c
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发表时间：
2020
影响因子：
4.9
通讯作者：
Hilty, Christian
中科院分区：
文献类型：
--
作者：
Pham, Pierce;Hilty, Christian
提出了一系列双齿N-杂环卡宾（NHC）铱催化剂[Ir（κC，N-NHC）H2 L2] BPh 4用于SABRE超极化。NHC的空间和电子性质用于调节底物亲和力，从而调节SABRE效率。空间位阻底物2，4-二氨基嘧啶和甲氧苄啶产生最大质子NMR信号增强分别为300倍和150倍。
A series of bidentate N-heterocyclic carbene (NHC) iridium catalysts, [Ir(κC,N-NHC)H2L2]BPh4, are proposed for SABRE hyperpolarization. The steric and electronic properties of the NHCs are used to tune substrate affinity and thereby SABRE efficiency. The sterically hindered substrates 2,4-diaminopyrimidine and trimethoprim yielded maximum proton NMR signal enhancements of ∼300-fold and ∼150-fold, respectively.