Preoperative chemotherapy for initially unresectable hepatoblastoma in children. Survival in two cases.
Preoperative chemotherapy for initially unresectable hepatoblastoma in children. Survival in two cases.
复制标题
儿童最初不可切除的肝母细胞瘤的术前化疗。
作者：
K. Ikeda;S. Suita;A. Nakagawara;K. Takabayashi
在两名患有肝母细胞瘤的儿童中，化疗的反应允许随后的手术切除。最初，在这两个患者中，由于肿瘤的大小和/或范围，被认为是不可切除的。用硫酸长春新碱和环磷酰胺化疗导致肿瘤大小显著减小，分别在治疗9个月和4个月后开腹切除。病例1肿瘤定位于右肝叶，行右肝叶切除术。病例2，肿瘤位于左右叶，但被包裹，可以通过肉眼完全切除切除肿瘤。术后11个月和23个月，两例患儿均生存良好，无肿瘤复发迹象。
In two children with hepatoblastoma, response to chemotherapy permitted subsequent surgical resection. Initially, in both patients, the tumor was thought to be unresectable because of size and/or extent. Chemotherapy with vincristine sulfate and cyclophosphamide resulted in substantial reduction in tumor size, and laparotomy for excision was performed after nine months and four months of therapy, respectively. In case 1, the tumor was localized in the right hepatic lobe and the right hepatic lobectomy was performed. In case 2, the tumor was located in both right and left lobes, but was encapsulated and it was possible to enucleate the tumor with complete gross excision. Both children are living and well without evidence of recurrence of tumor 11 and 23 months after operation.