A DOSE-ESCALATION STUDY OF LARGE DOSES OF NALOXONE FOR TREATMENT OF PATIENTS WITH ACUTE CEREBRAL-ISCHEMIA
A DOSE-ESCALATION STUDY OF LARGE DOSES OF NALOXONE FOR TREATMENT OF PATIENTS WITH ACUTE CEREBRAL-ISCHEMIA
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DOI：
10.1161/01.str.17.3.404
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发表时间：
1986-05-01
期刊：
影响因子：
8.3
通讯作者：
HOLLERN, R
中科院分区：
文献类型：
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作者：
ADAMS, HP;OLINGER, CP;HOLLERN, R
在27例患者中进行了一项剂量递增研究，以确定纳洛酮治疗急性脑缺血的最高安全剂量和潜在最佳剂量。所有患者均接受纳洛酮推注，然后以每小时50%的推注速率连续输注24小时。负荷剂量范围为2.5至200 mg/m2。患者总剂量范围为52.3 - 4978 mg。未发生主要剂量相关副作用。这项研究的目的不是确定纳洛酮在中风中的疗效，但在13名患者中观察到短暂或持续的改善。3例患者的神经系统状况在停用纳洛酮后3小时内恶化。我们的经验表明，纳洛酮值得进一步的治疗试验。
A dose-escalation study was performed in 27 patients to determine the highest safe and potentially optimal dose of naloxone for treatment of acute cerebral ischemia. All patients received a bolus of naloxone followed by a continuous 24 hour infusion at an hourly rate 50% of the bolus. Loading doses ranged from 2.5 to 200 mg/m2. Total patient doses ranged from 52.3 to 4978 mg. No major dose-related side effects occurred. This study was not designed to determine naloxone''s efficacy in stroke, but transient or sustained improvement was observed in 13 patients. Three patients'' neurological condition worsened within three hours after the naloxone was discontinued. Our experience suggests that further therapeutic trials of naloxone are worthwhile.