Influence of the severity of knee osteoarthritis on the association between leg muscle mass and quadriceps strength: the SPSS-OK study
Influence of the severity of knee osteoarthritis on the association between leg muscle mass and quadriceps strength: the SPSS-OK study
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膝骨关节炎严重程度对腿部肌肉质量和股四头肌力量之间关系的影响：SPSS-OK 研究
DOI：
10.1007/s10067-018-4337-2
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发表时间：
2018
影响因子：
3.4
通讯作者：
Mizuno Kiyonori
中科院分区：
文献类型：
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作者：
Wada Osamu;Kurita Noriaki;Kamitani Tsukasa;Nakano Naoki;Mizuno Kiyonori
股四头肌力量对于维持膝骨关节炎（OA）患者的功能性运动非常重要。我们的目的是研究膝关节骨性关节炎的严重程度是否削弱了腿部肌肉质量，股四头肌力量和功能运动之间的关联程度。科比研究骨科队列中肌肉减少症筛查（SPSS-OK）是一项单中心横断面研究。我们招募了611名膝关节OA患者。腿部肌肉质量通过生物阻抗测定，并用作股四头肌肌肉质量的代表。测量股四头肌强度和功能性运动指数（通过新膝关节学会评分问卷[KSS]的功能活动类别和计时起身和行走[TUG]测试进行评估）。膝关节OA严重程度由Kelling-Lawrence影像学分级确定。对一系列一般线性模型进行了拟合，并对混杂变量进行了调整。在膝关节OA 1/2、3和4级患者中，每条腿的股四头肌力量增加与每条腿的腿质量增加1 kg相关，分别为7.29 Nm、5.43 Nm和3.77 Nm（相互作用P = 0.003）。无论膝关节OA的严重程度如何，每条腿股四头肌力量增加1 Nm与KSS运动评分增加0.14分和TUG减少0.05 s相关（相互作用P <0.430和0.323）。严重的膝关节OA可能会降低腿部肌肉质量对股四头肌力量的发挥效率，即使肌肉质量的量保持不变。
Quadriceps strength is important for maintaining functional movement in patients with knee osteoarthritis (OA). We aimed to examine whether knee OA severity weakened the magnitude of the associations between leg muscle mass, quadriceps strength, and functional movement. Screening for People Suffering Sarcopenia in Orthopedic cohort of Kobe study (SPSS-OK) was a single-center cross-sectional study. We recruited 611 patients with knee OA. Leg muscle mass was determined by bioimpedance and used as a proxy for quadriceps muscle mass. Quadriceps strength and indices of functional movement (assessed by the functional activities category of the new Knee Society Score questionnaire [KSS] and the Timed Up and Go [TUG] test) were measured. Knee OA severity was determined by the Kellgren-Lawrence radiographic grade. A series of general linear models was fitted with adjustment for confounding variables. The increase in quadriceps strength per leg associated with a 1-kg increase in leg mass per leg was 7.29 Nm, 5.43 Nm, and 3.77 Nm among patients with knee OA grade 1/2, 3, and 4, respectively (Pfor interaction = 0.003). A 1-Nm increase in quadriceps strength per leg was associated with both a 0.14 point increase in KSS movement score and a 0.05 s decrease in TUG, regardless of knee OA severity (Pfor interaction 0.430 and 0.323). Severe knee OA may reduce efficiency in the exertion of quadriceps strength by leg muscle mass even when the amount of muscle mass remains unchanged.