Human Striatal Association Megaclusters.
Human Striatal Association Megaclusters.
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人类纹状体协会巨团。
DOI：
10.1101/2023.10.03.560666
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发表时间：
2023
期刊：
影响因子：
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通讯作者：
Buckner,RandyL
中科院分区：
文献类型：
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作者：
Kosakowski,HeatherL;Saadon-Grosman,Noam;Du,Jingnan;Eldaief,MarkE;Buckner,RandyL
纹状体接受来自大脑皮层多个区域的投射，与基底节在不同运动、情感和认知功能中的作用一致。在纹状体内，尾状核接受联合皮质的投射，包括前额叶皮质的多个不同区域。基于最近关于并列皮质网络如何专用于高级认知的不同方面的细节的见解，我们重新审视了尾状组织，最初在两个密集扫描的个体中使用个体内精确的神经成像(每个个体扫描了31次)。结果显示，尾状核具有并排的区域，这些区域与至少五个不同的分布的关联网络相连，与大脑皮层中观察到的组织平行。我们将这些区域的空间组合称为纹状体联合巨星团。放置在大星系团内的紧密并列的种子区域的相关图概括了五个不同的皮质网络，包括它们的多个空间分布区域。对另外15名参与者(每个人至少扫描了8次)进行了纹状体关联巨星团的研究，发现它们的存在适用于新的参与者。对巨型星系团内区域的偏侧性的分析进一步表明，它们具有与大脑皮层对应区域平行的不对称性。例如，与语言网络相连的尾状体区被偏向左侧。这些结果扩展了平行专门化基底节回路的一般概念，进一步发现，即使在尾状核内，也存在反映大脑皮层组织和偏侧化的多个不同的高阶网络的细粒度分离。NEW&NOTEWORTHYA个性化精确的神经成像方法显示了尾状核的并列区域，这些区域与联合皮质中的五个不同的网络相耦合。这些尾状带的组织概括了在大脑皮层观察到的组织，并扩展了专门的基底节回路的概念。
The striatum receives projections from multiple regions of the cerebral cortex consistent with the role of the basal ganglia in diverse motor, affective, and cognitive functions. Within the striatum, the caudate receives projections from association cortex, including multiple distinct regions of prefrontal cortex. Building on recent insights about the details of how juxtaposed cortical networks are specialized for distinct aspects of higher-order cognition, we revisited caudate organization using within-individual precision neuroimaging initially in two intensively scanned individuals (each scanned 31 times). Results revealed that the caudate has side-by-side regions that are coupled to at least five distinct distributed association networks, paralleling the organization observed in the cerebral cortex. We refer to these spatial groupings of regions as striatal association megaclusters. Correlation maps from closely juxtaposed seed regions placed within the megaclusters recapitulated the five distinct cortical networks, including their multiple spatially distributed regions. Striatal association megaclusters were explored in 15 additional participants (each scanned at least 8 times), finding that their presence generalizes to new participants. Analysis of the laterality of the regions within the megaclusters further revealed that they possess asymmetries paralleling their cortical counterparts. For example, caudate regions linked to the language network were left lateralized. These results extend the general notion of parallel specialized basal ganglia circuits with the additional discovery that, even within the caudate, there is fine-grained separation of multiple distinct higher-order networks that reflects the organization and lateralization found in the cerebral cortex.NEW & NOTEWORTHYAn individualized precision neuroimaging approach reveals juxtaposed zones of the caudate that are coupled with five distinct networks in association cortex. The organization of these caudate zones recapitulates organization observed in the cerebral cortex and extends the notion of specialized basal ganglia circuits.