[Effect of zonisamide on resting tremor resistant to antiparkinsonian medication].
[Effect of zonisamide on resting tremor resistant to antiparkinsonian medication].
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[唑尼沙胺对抗帕金森病药物抗静息性震颤的影响]。
DOI：
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发表时间：
2003
期刊：
影响因子：
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通讯作者：
T. Kondo
中科院分区：
文献类型：
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作者：
I. Nakanishi;J. Kohmoto;H. Miwa;T. Kondo
唑尼沙胺(ZNS)是一种抗癫痫药，其抗帕金森病作用已有报道。一般来说，帕金森病患者的静止性震颤不是本病的主要治疗靶点。然而，根据患者的社会状况，震颤的改善可能是必要的。在这项研究中，我们考察了9名希望震颤改善的患者服用ZNS对震颤的影响。除了震颤，根据他们的日常活动，他们似乎处于最佳治疗状态。通过补充服用ZNS，9名患者中有7名的震颤程度有所减轻(P<；0.0017)。尽管一名患者感到困倦，两名患者有一过性食欲不振，但所有患者都能耐受为期8周的ZNS服药期。大多数患者的最终剂量为100 mg/d。虽然ZNS的抗颤作用机制尚不清楚，但除了促进多巴胺能传递外，该药对震颤可能存在一些特异的作用。要进行更详细的随机抽查。
The antiparkinsonian effect of zonisamide (ZNS), an antiepileptic agent, has been reported. Generally, resting tremor of patients with Parkinson's disease is not the main therapeutic target in this disease. However, depending on the social situation of the patient, the amelioration of the tremor may be necessary. In this study, we examined the effect of ZNS on tremor in nine patients who desired amelioration of their tremor. Except for tremor, they seemed to be under optimal therapeutic condition based on their daily activities. By the add-on administration of ZNS, the degree of tremor was reduced in seven out of nine patients (p < 0.0017). Although one patient felt sleepiness and two patients had a transient loss of appetite, all the patients tolerated the eight-week ZNS administration period. The final dose of ZNS was 100 mg/day in the majority of the patients. Although the mechanism of the antitremulous effect of ZNS is not yet clear, other than the enhancement of dopaminergic transmission, some specific action of the drug on tremor may exist. A more detailed random examination should be carried out.