β-Adrenergic receptors enhance excitatory transmission in the bed nucleus of the stria terminalis through a corticotrophin-releasing factor receptor-dependent and cocaine-regulated mechanism.
β-Adrenergic receptors enhance excitatory transmission in the bed nucleus of the stria terminalis through a corticotrophin-releasing factor receptor-dependent and cocaine-regulated mechanism.
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DOI：
10.1016/j.biopsych.2010.12.030
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发表时间：
2011-06-01
影响因子：
10.6
通讯作者：
Winder, Danny G.
中科院分区：
文献类型：
--
作者：
Nobis, William P.;Kash, Thomas L.;Silberman, Yuval;Winder, Danny G.
有证据表明，去甲肾上腺素能和促肾上腺皮质激素释放因子（CRF）系统在复发和应激相关行为中起关键作用。特别是，行为研究指出，β-肾上腺素能受体启动的一系列信号传导过程需要终纹床核（BNST）中的CRF受体（CRFR）依赖性信号传导，以产生应激诱导的可卡因寻求复发。我们使用急性制备的小鼠脑片的全细胞膜片钳记录来检查β-肾上腺素能受体和CRFR 1在BNST中兴奋性传递的作用。我们检查了这些受体的激动剂的作用，从幼稚，假，可卡因条件小鼠制备的切片。BNST内的β1-肾上腺素能受体激活产生需要CRFR 1依赖性信号传导的兴奋性突触传递的增强。我们发现，长期可卡因给药短暂地破坏β1-肾上腺素能和CRFR 1依赖性增强的多巴胺能传递，这种破坏随着时间的推移减弱，它可以重新引入可卡因的挑战。总之，这些研究确定了BNST内的电路机制，可能在CRF和NE调节行为中发挥重要作用。
Evidence suggests that the noradrenergic and corticotrophin-releasing factor (CRF) systems play critical roles in relapse and stress related behaviors. In particular, behavioral studies point to a serial signaling process initiated by β-adrenergic receptors that requires CRF receptor (CRFR)-dependent signaling in the bed nucleus of the stria terminalis (BNST) to produce stress-induced relapse to cocaine seeking. We used whole cell patch clamp recordings from acutely prepared mouse brain slices to examine the actions of β-adrenergic receptors and CRFR1 on excitatory transmission in BNST. We examined the effects of agonists of these receptors in slices prepared from naïve, sham, and cocaine conditioned mice. β1-adrenergic receptor activation within the BNST produces an enhancement of excitatory synaptic transmission that requires CRFR1-dependent signaling. We show that chronic cocaine administration transiently disrupts β1-adrenergic- and CRFR1-dependent enhancement of glutamatergic transmission, that this disruption wanes with time, and that it can be reintroduced with a cocaine challenge. In total, these studies identify a circuit mechanism within the BNST that may play an important role in CRF and NE regulated behaviors.
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DOI：
10.1523/jneurosci.5129-08.2009
发表时间：
2009-04-29
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Francesconi W;Berton F;Repunte-Canonigo V;Hagihara K;Thurbon D;Lekic D;Specio SE;Greenwell TN;Chen SA;Rice KC;Richardson HN;O'Dell LE;Zorrilla EP;Morales M;Koob GF;Sanna PP
通讯作者：
Sanna PP
影响因子：
10.6
作者：
Koob, GF
通讯作者：
Koob, GF
影响因子：
5.3
作者：
Erb, S;Shaham, Y;Stewart, J
通讯作者：
Stewart, J
影响因子：
3.3
作者：
Funk, D;Li, Z;Lê, AD
通讯作者：
Lê, AD
影响因子：
3.4
作者：
Buffalari, Deanne M.;See, Ronald E.
通讯作者：
See, Ronald E.