MECHANISMS AND PHYSIOLOGICAL ROLES OF FATTY-ACID CHAIN ELONGATION IN MICROSOMES AND MITOCHONDRIA
MECHANISMS AND PHYSIOLOGICAL ROLES OF FATTY-ACID CHAIN ELONGATION IN MICROSOMES AND MITOCHONDRIA
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DOI：
10.1007/bf01659936
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发表时间：
1973-01-01
影响因子：
4.3
通讯作者：
PODACK, ER
中科院分区：
文献类型：
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作者：
SEUBERT, W;PODACK, ER
1.从大鼠肝脏中分离纯化了两种具有不同催化性质的烯酰辅酶A还原酶，2.亚细胞定位研究表明，这两种酶分别是线粒体和微粒体脂肪酸链延长系统的组成部分，3.微粒体酶对己烯酰辅酶A具有最佳活性，线粒体烯酰辅酶A还原酶对癸烯酰辅酶A具有最佳活性。γ-亚麻酸和亚麻酸分别作为微粒体和线粒体烯酰辅酶A还原酶的生理底物，这一观察结果的意义将被讨论。4.大鼠肝脏和心脏的线粒体烯酰辅酶A还原酶具有不同的吡啶核苷酸特异性。讨论了这些差异在血管生成或氮代谢以及能量守恒中的重要作用。5.讨论了主动脉线粒体脂肪酸链延长与动脉粥样硬化发病机制之间的可能关系。
1.The characterization and separation of two enoyl-CoA reductases from rat liver with different catalytic properties are described.2.Studies on the subcellular location revealed both enzymes to be constituents of a mitochondrial and microsomal fatty acid chain elongation system, respectively.3.The microsomal enzyme shows optimal activity with hexenoyl-CoA, the mitochondrial enoyl-CoA reductase with decenoyl-CoA. The implications of this observation regarding a preference for γ-linolenic acid and linolenic acid, respectively, as the physiological substrates of microsomal and mitochondrial enoyl-CoA reductase will be discussed.4.The mitochondrial enoyl-CoA reductases from rat liver and heart exhibit different pyridine nucleotide specificities. The implications of these differences concerning important roles in gluconeogenesis or nitrogen metabolism and in conservation of energy, respectively, is discussed.5.A possible relationship between mitochondrial fatty acid chain elongation in the aorta and the pathogenesis of atherosclerosis is discussed.