A single IGF1 allele is a major determinant of small size in dogs
A single IGF1 allele is a major determinant of small size in dogs
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DOI：
10.1126/science.1137045
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发表时间：
2007-04-06
期刊：
影响因子：
56.9
通讯作者：
Ostrander, Elaine A.
中科院分区：
文献类型：
--
作者：
Sutter, Nathan B.;Bustamante, Carlos D.;Ostrander, Elaine A.
家犬在体型上比其他任何陆生脊椎动物都具有更大的多样性。我们采用了一种利用狗的品种结构来研究大小的遗传基础的策略。首先，通过全基因组扫描，我们确定了15号染色体上影响单个品种大小变化的主要数量性状位点（QTL）。其次，我们检查了小品种和大品种QTL周围15兆碱基区间的遗传变异，发现了编码胰岛素样生长因子1的单个基因（IGF1）选择性扫描的明显证据。单个IGF1单核苷酸多态性单倍型在所有小型犬种中都很常见，而在大型犬种中几乎没有，这表明相同的因果序列变异是所有小型犬体型的主要贡献者。
The domestic dog exhibits greater diversity in body size than any other terrestrial vertebrate. We used a strategy that exploits the breed structure of dogs to investigate the genetic basis of size. First, through a genome-wide scan, we identified a major quantitative trait locus (QTL) on chromosome 15 influencing size variation within a single breed. Second, we examined genetic variation in the 15-megabase interval surrounding the QTL in small and giant breeds and found marked evidence for a selective sweep spanning a single gene (IGF1), encoding insulin-like growth factor 1. A single IGF1 single-nucleotide polymorphism haplotype is common to all small breeds and nearly absent from giant breeds, suggesting that the same causal sequence variant is a major contributor to body size in all small dogs.