MONOCLONAL-ANTIBODY MAPPING OF KERATIN-8 AND KERATIN-17 AND OF VIMENTIN IN NORMAL HUMAN MAMMARY-GLAND, BENIGN-TUMORS, DYSPLASIAS AND BREAST-CANCER
MONOCLONAL-ANTIBODY MAPPING OF KERATIN-8 AND KERATIN-17 AND OF VIMENTIN IN NORMAL HUMAN MAMMARY-GLAND, BENIGN-TUMORS, DYSPLASIAS AND BREAST-CANCER
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DOI：
10.1002/ijc.2910420202
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发表时间：
1988-08-15
影响因子：
6.4
通讯作者：
BANNIKOV, GA
中科院分区：
文献类型：
--
作者：
GUELSTEIN, VI;TCHYPYSHEVA, TA;BANNIKOV, GA
本文用单抗HI、E3和NT30分别对28例正常人乳腺组织、16例良性肿瘤、26例纤维细胞性疾病和52例恶性乳腺肿瘤组织中角蛋白8、17和波形蛋白的分布进行了研究。在正常乳腺上皮中已鉴定出三种细胞群：含角蛋白8的腔上皮、小叶结构的肌上皮和角蛋白17阳性的小叶外导管的肌上皮。在不同类型的良性肿瘤和异型增生中，均可观察到具有所有正常表型的细胞的马赛克。大多数细胞共表达角蛋白8和17或波形蛋白。在绝大多数癌中，细胞不含肌上皮标志物(角蛋白17和波形蛋白)，但仅表达正常腔上皮所特有的角蛋白8。
The distribution of keratins 8 and 17 and of vimentin in 28 normal human mammary tissue samples, 16 benign tumors, 26 fibrocytic diseases and 52 maligant breast tumors have been studied using monoclonal antibodies HI, E3 and NT30, respectively. Three cell populations in normal mammary epithelium have been identified: luminal epithelium containing keratin 8, myoepithelium of the lobular structures positive for vimenin, and myoepithelium of extralobular ducts positive for keratin 17. In different kinds of benign tumor and dysplastic proliferation a mosaic of cells with all normal phenotypes has been observed. The majority of cells co-expressed keratins 8 and 17 or vimentin. In the overwhelming majority of carcinomas, cells did not contain myoepithelial markers (keratin 17 and vimentin) but expressed only keratin 8 specific to normal luminal epithelium.