Immunological imprinting of the antibody response in COVID-19 patients.
Immunological imprinting of the antibody response in COVID-19 patients.
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DOI：
10.1038/s41467-021-23977-1
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发表时间：
2021-06-18
影响因子：
16.6
通讯作者：
García-Sastre A
中科院分区：
文献类型：
--
作者：
Aydillo T;Rombauts A;Stadlbauer D;Aslam S;Abelenda-Alonso G;Escalera A;Amanat F;Jiang K;Krammer F;Carratala J;García-Sastre A
除了严重急性呼吸综合征冠状病毒2型（SARS-CoV-2），人类还对其他六种冠状病毒易感，对于这些冠状病毒，连续暴露于抗原相关和不同的季节性冠状病毒是频繁的。尽管COVID-19大流行和正在进行的研究，但针对严重急性呼吸道综合征冠状病毒2（SARS-CoV-2）的抗体反应的性质尚不清楚。在这里，我们纵向分析了2019年冠状病毒病（COVID-19）住院患者对SARS-CoV-2的早期体液免疫应答，并量化了对OC 43，HKU 1和229 E季节性冠状病毒的既存免疫水平，并发现OC 43和HKU 1 β冠状病毒刺突蛋白的保守但非可变区具有强烈的反向增强效应。然而，这种对人冠状病毒的抗体记忆增强与针对SARS-CoV-2刺突蛋白和核衣壳蛋白的IgG和IgM的诱导呈负相关。因此，我们的研究结果提供了以前的季节性冠状病毒感染的免疫印迹的证据，可以潜在地调节SARS-CoV-2感染的抗体谱。除SARS-CoV-2外，其他冠状病毒也感染人类，但连续感染是否交叉调节诱导的免疫反应仍不清楚。在这里，作者表明，SARS-CoV-2感染增强了对其他冠状病毒的预先存在的反应，但这种反向增强阻碍了针对SARS-CoV-2的特异性抗体的诱导。
In addition to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), humans are also susceptible to six other coronaviruses, for which consecutive exposures to antigenically related and divergent seasonal coronaviruses are frequent. Despite the prevalence of COVID-19 pandemic and ongoing research, the nature of the antibody response against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is unclear. Here we longitudinally profile the early humoral immune response against SARS-CoV-2 in hospitalized coronavirus disease 2019 (COVID-19) patients and quantify levels of pre-existing immunity to OC43, HKU1 and 229E seasonal coronaviruses, and find a strong back-boosting effect to conserved but not variable regions of OC43 and HKU1 betacoronaviruses spike protein. However, such antibody memory boost to human coronaviruses negatively correlates with the induction of IgG and IgM against SARS-CoV-2 spike and nucleocapsid protein. Our findings thus provide evidence of immunological imprinting by previous seasonal coronavirus infections that can potentially modulate the antibody profile to SARS-CoV-2 infection. In addition to SARS-CoV-2, other coronaviruses also infect human, but whether consecutive infections cross-modulate the induced immune response is still unclear. Here the authors show that SARS-CoV-2 infection boosts pre-existing responses to other coronaviruses, yet such back-boosting hampers the induction of specific antibodies against SARS-CoV-2.