Relationship between response to phenelzine and MAO inhibition in a clinical trial of phenelzine, amitriptyline and placebo.
Relationship between response to phenelzine and MAO inhibition in a clinical trial of phenelzine, amitriptyline and placebo.
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苯乙肼、阿米替林和安慰剂临床试验中苯乙肼反应与 MAO 抑制之间的关系。
DOI：
10.1159/000117841
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发表时间：
1981
影响因子：
3.2
通讯作者：
Mattox,A
中科院分区：
文献类型：
--
作者：
Raft,D;Davidson,J;Wasik,J;Mattox,A
这份报告检验了苯乙肼要比安慰剂更有效的假设，它需要达到至少80%的抑制血小板MAO活性。这一假设是在抑郁症患者中苯乙肼、阿米替林和安慰剂的双盲比较的背景下进行检验的。4周后，当苯乙肼显著优于安慰剂时，MAO的平均抑制率为85%。第5周，MAO抑制率达90%以上时，苯乙肼明显优于阿米替林。在苯乙肼组中，改善和MAO抑制之间存在高度显著的相关性。
This report examines the hypothesis that for phenelzine to be more effective than placebo it is necessary to achieve at least 80% inhibition of platelet MAO activity. This hypothesis was examined in the context of a double-blind comparison of phenelzine, amitriptyline and placebo in depressed patients. When phenelzine became significantly more effective than placebo at 4 weeks, the average MAO inhibition was 85%. By the 5th week, with MAO inhibition greater than 90%, phenelzine was significantly more effective than amitriptyline. A highly significant correlation was noted between improvement and MAO inhibition within the phenelzine group.