Chronic exposure to aldicarb-contaminated groundwater and human immune function.
Chronic exposure to aldicarb-contaminated groundwater and human immune function.
复制标题
长期接触涕灭威污染的地下水与人体免疫功能。
DOI：
10.1016/s0013-9351(86)80157-8
复制
发表时间：
1986
影响因子：
8.3
通讯作者：
D. Belluck
中科院分区：
文献类型：
--
作者：
M. C. Fiore;H. Anderson;R. Hong;R. Golubjatnikov;J. E. Seiser;D. Nordstrom;L. Hanrahan;D. Belluck
Aldicarb, a carbamate pesticide, has been a known groundwater contaminant in Wisconsin since 1981. To assess the effects of chronic ingestion of low-level aldicarb-contaminated groundwater (<61 ppb) on the immune function of humans, we identified 50 women, ages 18 to 70, with no known underlying reason for immunodysfunction. Twenty-three of these women (exposed group) consumed groundwater with detectable levels of aldicarb, and 27 (unexposed group) consumed water from a source with no detectable levels of aldicarb. Data were collected on each woman's health status, immune function, and fluid intake. Exposed women as compared with unexposed women showed an elevated stimulation assay response to the antigenCandida(P<0.02,ttest). The exposed group had increased numbers of T8 cells (P<0.05,ttest), an increased percentage of total lymphocytes as T8 cells (P<0.02,ttest), and a decreased ratio of T4:T8 cells (P<0.02,ttest). Our results suggest an association between consumption of aldicarb-contaminated groundwater and abnormalities in T-cell subsets in women with otherwise intact immune systems.
ELISA 检测人血清中大肠杆菌、破伤风类毒素和白喉-破伤风类毒素的特异性功能抗体：IgG、IgA 和 IgM 的正常值。
DOI：
--
发表时间：
1986
期刊：
Diagnostic immunology
影响因子：
--
作者：
Moen,RC;Oemichen,SL;Kiggens,AJ;Hong,R
通讯作者：
Hong,R