Novel Application of α-Azido Aldehydes in Multicomponent Reactions: Synthesis of Triazolo-Fused Dihydrooxazinones via a Passerini Reaction-Dipolar Cycloaddition Strategy
Novel Application of α-Azido Aldehydes in Multicomponent Reactions: Synthesis of Triazolo-Fused Dihydrooxazinones via a Passerini Reaction-Dipolar Cycloaddition Strategy
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DOI：
10.1021/co200072z
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发表时间：
2011-09-01
影响因子：
--
通讯作者：
Basso, Andrea
中科院分区：
文献类型：
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作者：
De Moliner, Fabio;Crosignani, Stefano;Basso, Andrea
α-叠氮基醛可用于与异氰化物和各种丙炔酸的Passerini反应中，以中等至良好的产率得到三组分加合物。这些化合物经过直接的叠氮-炔偶极环加成反应得到三唑并稠合的二氢恶嗪酮。
alpha-Azido aldehydes can be employed in Passerini reactions with isocyanides and various propiolic acids to afford the three-component adducts in moderate to good yields. These compounds undergo a straightforward azide-alkyne dipolar cycloaddition to furnish triazolo-fused dihydrooxazinones.