Evaluation of the Ophthalmotoxic Effect of Quantum Dots InP/ZnSe/ZnS 660 and Bioconjugates Based on Them in Terms of the Prospects for the Treatment of Resistant Endophthalmitis. Experimental Research. Part 2 (Stage 1)
Evaluation of the Ophthalmotoxic Effect of Quantum Dots InP/ZnSe/ZnS 660 and Bioconjugates Based on Them in Terms of the Prospects for the Treatment of Resistant Endophthalmitis. Experimental Research. Part 2 (Stage 1)
复制标题
量子点InP/ZnSe/ZnS 660及基于其的生物共轭物的眼毒性作用评价及其治疗耐药性眼内炎的前景。
DOI：
10.18008/1816-5095-2021-4-876-884
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发表时间：
2021
期刊：
影响因子：
--
通讯作者：
V. V. Marysheva
中科院分区：
文献类型：
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作者：
V. O. Ponomarev;V. Kazaykin;A. V. Lizunov;A. Vokhmintsev;I. A. Vainshtein;S. Dezhurov;V. V. Marysheva
现代医学中的化疗/抗生素耐药性问题今天仍然相关。微生物（MO）的敏感性决定了所用药物的范围，最终影响治疗的有效性和患者的预后。然而，考虑到MO的个体菌株的适应过程，抗生素的不受控制的使用将不可避免地导致在世界范围内维持所谓的抗生素耐药性危机，以及形成恶性循环，减少任何炎症性疾病（包括眼科疾病）治疗的功能和解剖结果。本文介绍了实验创建和认证的过程，量子点的物理化学性质的评估，以及生物纳米复合物作为一种选择，用于克服某些菌株的微生物在眼科感染和炎症病理学治疗中的抗生素耐药性，特别是眼内炎。此外，动物模型已经证明了使用InP / ZnSe / ZnS 660量子点溶液以纯形式和与抗生素组合用于玻璃体内施用的安全性。
The problem of chemo/antibiotic resistance in modern medicine remains relevant today. The sensitivity of microorganisms (MO) determines the range of drugs used, which ultimately affects the effectiveness of treatment and the prognosis for the patient. However, taking into account the adaptation process of individual strains of MO, the uncontrolled use of antibiotics will inevitably lead to the maintenance of the so-called crisis of antibiotic resistance throughout the world, as well as the formation of a vicious circle that reduces the functional and anatomical outcomes of the treatment of any inflammatory diseases, including ophthalmological ones. This article presents the process of experimental creation and certification, assessment of the physicochemical properties of quantum dots, as well as biological nanoconjugates as an option for overcoming the antibiotic resistance of certain strains of microorganisms in the treatment of infectious and inflammatory pathology in ophthalmology, in particular endophthalmitis. Also, an animal model has demonstrated the safety of using InP / ZnSe / ZnS 660 quantum dot solutions for intravitreal administration in pure form and in combination with antibiotics.