The prevalence of serum antibody to human herpesvirus 8 (Kaposi sarcoma-associated herpesvirus) among HIV-seropositive and high-risk HIV-seronegative women
The prevalence of serum antibody to human herpesvirus 8 (Kaposi sarcoma-associated herpesvirus) among HIV-seropositive and high-risk HIV-seronegative women
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DOI：
10.1001/jama.277.6.478
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发表时间：
1997-02-12
影响因子：
120.7
通讯作者：
Greenblatt, R
中科院分区：
文献类型：
--
作者：
Kedes, DH;Ganem, D;Greenblatt, R
目的：确定已知感染人类免疫缺陷病毒1型(HIV-1)或艾滋病毒感染高风险的妇女中人类疱疹病毒8型(HHV-8)血清阳性的流行率。设计-一项横断面盲法研究，通过使用潜伏感染HHV-8的细胞的细胞核的间接免疫荧光分析来确定HHV-8感染的血清学反应性的流行率。数据和样本是在一项纵向自然历史队列研究的基线评估中收集的。背景-参加队列研究的四家旧金山湾区艾滋病毒门诊专科诊所。患者。-在妇女机构间艾滋病毒研究中，共有387名参与者的艾滋病毒感染状况被记录在案，血清可在当地样本储存库中获得。主要结果衡量标准。-对HV-8的血清学反应性。结果：研究参与者对潜在的HHV-8抗原的血清学反应性是罕见的：13人(3.4%)表现出血清抗体。HHV-8反应在HIV感染的妇女中更为常见；在302名HIV感染的参与者中有12人(4.0%；95%可信区间[CI]，2.1%~6.9%)与84名未感染HIV的参与者中的1人(1.2%；95%CI，0.03%~6.4%)HHV-8血清阳性，但差异无统计学意义(优势比=3.43；95%CI，0.49~148.6)。其中两名感染艾滋病毒的妇女有Kaposi肉瘤病变，两人都是血清阳性。结论：艾滋病毒感染妇女组中HHV-8血清阳性的发生率大大低于最近报道的感染艾滋病毒的同性恋和双性恋男子中的HHV-8感染率(30%-35%)。这一发现与女性卡波西肉瘤的发病率低于感染艾滋病毒的男性的情况形成了对比。这些数据进一步扩大了HHV-8血清反应性与Kaposi肉瘤风险的相关性，并与HHV-8感染在Kaposi肉瘤发生中的重要作用一致。
Objective.-To determine the prevalence of human herpesvirus 8 (HHV-8) seropositivity among women who are known to be infected with human immunodeficiency virus type 1 (HIV-1) or who are at high risk for HIV infection.Design.-A cross-sectional and blinded study of the prevalence of serological reactivity to HHV-8 infection as determined by an indirect immunofluorescence assay using nuclei from cells latently infected with HHV-8. Data and specimens were collected at baseline assessments of a longitudinal natural history cohort study.Setting.-Four San Francisco Bay Area outpatient HIV specialty clinics participating in the cohort study.Patients.-A total of 387 participants in the Women's Interagency HIV Study whose HIV infection status was documented and serum was available in a local specimen repository.Main Outcome Measure.-Serological reactivity to HHV-8.Results.-Serological reactivity to latent HHV-8 antigens was uncommon among study participants: 13 (3.4%) demonstrated serum antibodies. HHV-8 reactivity was more common among HIV-infected women; 12 (4.0%; 95% confidence interval [CI], 2.1%-6.9%) of the 302 HIV-infected participants vs 1 (1.2%; 95% CI, 0.03%-6.4%) of the 84 HIV-uninfected participants were seropositive for HHV-8, though the difference did not attain statistical significance (odds ratio=3.43; 95% CI, 0.49-148.6). Two of the HIV-infected women had Kaposi sarcoma lesions and both were seropositive.Conclusions.-The prevalence of HHV-8 seropositivity among the group of HIV-infected women was dramatically lower than that recently reported among HIV-infected homosexual and bisexual men (30%-35%). This finding parallels the lower prevalence of Kaposi sarcoma among women in contrast to men with HIV infection. These data further extend the correlation of HHV-8 serological reactivity with risk of Kaposi sarcoma and are consistent with an important role for HHV-8 infection in development of Kaposi sarcoma.