A mini-review on quantification of atherosclerosis in hypercholesterolemic mice.
A mini-review on quantification of atherosclerosis in hypercholesterolemic mice.
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DOI：
10.36922/gtm.v1i1.76
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发表时间：
2022-01-01
期刊：
影响因子：
--
通讯作者：
Lu, Hong S
中科院分区：
文献类型：
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作者：
Chen, Hui;Howatt, Deborah A;Lu, Hong S
动脉粥样硬化是许多国家发病率和死亡率的主要原因。小鼠是研究动脉粥样硬化发病机制和分子机制最常用的动物模型。主动脉和主动脉根部横截面的正面分析是量化小鼠动脉粥样硬化严重程度的两种常见模式。这篇简短的综述介绍了这两种方法，讨论了它们的优缺点，并提出了优化动脉粥样硬化定量的建议，从而提高了临床前研究的严谨性和重复性。
Atherosclerosis is a leading cause of morbidity and mortality in many countries. Mice are the most frequently used animal model to study the pathogenesis and molecular mechanisms of atherosclerosis. En face analyses of the aorta and cross-sections of the aortic root are the two common modes for quantifying the severity of atherosclerosis in mice. This mini-review introduces these two methods, discusses their pros and cons, and provides suggestions to optimize the quantification of atherosclerosis, thereby enhancing rigor and reproducibility in preclinical research.