A clinicopathologic study of transient osteoporosis of the hip
A clinicopathologic study of transient osteoporosis of the hip
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DOI：
10.1007/s002560050563
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发表时间：
1999-11-01
影响因子：
2.1
通讯作者：
Sueishi, K
中科院分区：
文献类型：
--
作者：
Yamamoto, T;Kubo, T;Sueishi, K
Objective.有人提出，髋关节一过性骨质疏松症（TOH）可能代表股骨头坏死（ON）的早期可逆阶段。本研究的目的是探讨三例TOH的临床病理特征。设计和患者。对三名根据临床病程、X线片、骨密度图和MR图像诊断为TOH的患者进行骨活检。对活检标本进行光镜和电镜观察。TOH最具特征性的特征是局灶性的薄而不连续的骨小梁被类骨质缝和活跃的成骨细胞覆盖。周围骨髓组织显示水肿变化和轻度纤维化，通常与血管充血和/或间质出血相关。在骨小梁或骨髓组织中均未观察到骨坏死区域。所有患者的临床症状均得到改善，在3.5-9年的随访中没有显示ON的证据。本研究支持髋关节一过性骨质疏松症是一个独特的实体的概念。
Objective. It has been proposed that transient osteoporosis of the hip (TOH) may represent the early reversible phase of osteonecrosis of the femoral head (ON). The purpose of this study was to investigate the clinicopathologic characteristics of three cases of TOH.Design and patients. A bone biopsy was performed on three patients who had been diagnosed as having TOH based on the clinical course, radiograph, bone scintigram, and MR images. The biopsy specimens were studied histopathologically by light and electron microscopy.Results. The most characteristic feature of TOH was focal areas of thin and disconnected bone trabeculae covered by osteoid seams and active osteoblasts. The surrounding bone marrow tissue showed edematous changes and mild fibrosis, frequently associated with vascular congestion and/or interstitial hemorrhage. No osteonecrotic region was observed in either the bone trabeculae or the bone marrow tissue. All patients have improved clinically and in the 3.5-9 years of follow-up have shown no evidence of ON.Conclusions. This study supports the concept that transient osteoporosis of the hip is a distinct entity.