RAF22, ABI1 and OST1 form a dynamic interactive network that optimizes plant growth and responses to drought stress in Arabidopsis
RAF22, ABI1 and OST1 form a dynamic interactive network that optimizes plant growth and responses to drought stress in Arabidopsis
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RAF22、ABI1 和 OST1 形成动态交互网络，优化拟南芥植物生长和对干旱胁迫的响应
DOI：
10.1016/j.molp.2022.06.001
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发表时间：
2022
期刊：
影响因子：
27.5
通讯作者：
Zhizhong Gong
中科院分区：
文献类型：
--
作者：
Zhihui Sun;Zhenkai Feng;Yanglin Ding;Yuanpeng Qi;Shan Jiang;Zhen Li;Yu Wang;Junsheng Qi;Chunpeng Song;Shuhua Yang;Zhizhong Gong
Plants adapt to their ever-changing environment via positive and negative signals induced by environmental stimuli. Drought stress, for instance, induces accumulation of the plant hormone abscisic acid (ABA), triggering ABA signal transduction. However, the molecular mechanisms for switching between plant growth promotion and stress response remain poorly understood. Here we report that RAF (rapidly accelerated fibrosarcoma)-LIKE MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 22 (RAF22) inArabidopsis thalianaphysically interacts with ABA INSENSITIVE 1 (ABI1) and phosphorylates ABI1 at Ser416 residue to enhance its phosphatase activity. Interestingly, ABI1 can also enhance the activity of RAF22 through dephosphorylation, reciprocally inhibiting ABA signaling and promoting the maintenance of plant growth under normal conditions. Under drought stress, however, the ABA-activated OPEN STOMATA1 (OST1) phosphorylates the Ser81 residue of RAF22 and inhibits its kinase activity, restraining its enhancement of ABI1 activity. Taken together, our study reveals that RAF22, ABI1, and OST1 form a dynamic regulatory network that plays crucial roles in optimizing plant growth and environmental adaptation under drought stress.
