Microbiology of antibiotic resistance in Staphylococcus aureus
Microbiology of antibiotic resistance in Staphylococcus aureus
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DOI：
10.1086/519474
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发表时间：
2007-09-15
影响因子：
11.8
通讯作者：
Appelbaum, Peter C.
中科院分区：
文献类型：
--
作者：
Appelbaum, Peter C.
耐甲氧西林金黄色葡萄球菌（MRSA）分离株在引入甲氧西林后不久就出现了。从历史上看，MRSA分离株与医院感染有关，并迅速对多种药物产生耐药性。但近年来，社区中出现了具有独特表型的不同菌株，社区相关MRSA的储存库正在迅速扩大。社区相关病原体可能导致危及生命的全身感染，尤其是在儿童和老年人中，也可能导致健康个体严重的皮肤和软组织感染。与医院内菌株相比，社区相关MRSA分离株与毒力增加相关，目前更可能对多种抗生素敏感。社区相关和医院内MRSA感染之间的流行病学和微生物学差异需要不同的策略来预防和治疗这两种类型的感染。万古霉素不敏感的S。金黄色葡萄球菌呈增加趋势，使治疗进一步复杂化。
Methicillin-resistant Staphylococcus aureus ( MRSA) isolates came into existence soon after the introduction of methicillin. Historically, MRSA isolates have been associated with nosocomial infections and rapidly developed resistance to multiple drug classes. However, in recent years, different strains with unique phenotypes have emerged in the community, and the reservoir of community- associated MRSA is rapidly expanding. Community- associated pathogens are likely to cause life- threatening systemic infections, especially in children and elderly individuals, and may also cause serious skin and soft- tissue infections in healthy individuals. Compared with nosocomial strains, community- associated MRSA isolates are associated with increased virulence and currently are more likely to be susceptible to a variety of antibiotics. The epidemiological and microbiological differences between community- associated and nosocomial MRSA infections necessitate different strategies to prevent and treat the 2 types of infections. Vancomycin nonsusceptibility in S. aureus is on the increase, further complicating therapy.